Cardiac troponin after percutaneous coronary intervention and 1-year mortality in Non-ST-segment elevation acute coronary syndrome using systematic evaluation of biomarker trends

Pierluigi Tricoci, Sergio Leonardi, Jennifer White, Harvey D. White, Paul W. Armstrong, Gilles Montalescot, Robert P. Giugliano, C. Michael Gibson, Frans Van De Werf, Robert M. Califf, Robert A. Harrington, Eugene Braunwald, Kenneth W. Mahaffey, L. Kristin Newby

Research output: Contribution to journalArticle

Abstract

Objectives This study sought to review cardiac troponin (cTn) trends during non-ST-segment elevation acute coronary syndrome (NSTE ACS) in patients undergoing percutaneous coronary intervention (PCI) in the EARLY ACS (Early Glycoprotein IIb/IIIa Inhibition in Non-ST-Segment Elevation Acute Coronary Syndromes) and SYNERGY (Superior Yield of the New Strategy of Enoxaparin, Revascularization and Glycoprotein IIb/IIIa Inhibitors) studies and to study the relationship between post-PCI cTn and mortality. Background The prognostic value of cTn post-PCI is controversial. In patients with NSTE ACS, it is especially difficult to distinguish between cTn elevations due to PCI or index myocardial infarction (MI). Methods Time and cTn (indexed by upper limit of normal [ULN]) data pairs were plotted for 10,199 patients and independently reviewed by 2 physicians to identify patients in whom post-PCI cTn elevation could be distinguished from that of index MI. Post-PCI cTn peak was identified for each plot, and its relationship with 1-year mortality was evaluated using Cox modeling, correcting for 15 clinical variables from the EARLY ACS 1-year mortality model (including baseline cTn). We used an identical methodology to assess the association between creatine kinase-myocardial band and 1-year mortality. Results Patients with cTn (re-)elevation post-PCI not evaluable were identified and excluded from further analysis (4,198 [41%] with cTn rising prior to PCI; 229 [2%] with missing cTn). Among the remainder (n = 5,772 [57%]), in the multivariable model, peak cTn post-PCI was associated with a 7% increase in mortality (hazard ratio [HR] for 10× ULN increase: 1.07, 95% confidence interval [CI]: 1.02 to 1.11; p = 0.0038). Peak post-PCI creatine kinase-myocardial band was significantly associated with 1-year mortality (HR for 1× ULN increase: 1.13, 95% CI: 1.05 to 1.21; p = 0.0013). Conclusions We used a methodology that differentiated post-PCI cTn (re-)elevation from that of presenting MI in more than one-half of patients with NSTE ACS undergoing PCI. This identified a highly significant relationship between post-PCI cTn and 1-year mortality, with implications for both incorporating a cTn post-PCI MI definition and preventing PCI-related myonecrosis.

Original languageEnglish
Pages (from-to)242-251
Number of pages10
JournalJournal of the American College of Cardiology
Volume62
Issue number3
DOIs
Publication statusPublished - Jul 16 2013

Keywords

  • acute coronary syndrome(s)
  • mortality
  • myocardial infarction
  • percutaneous coronary intervention
  • troponin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Tricoci, P., Leonardi, S., White, J., White, H. D., Armstrong, P. W., Montalescot, G., Giugliano, R. P., Gibson, C. M., Van De Werf, F., Califf, R. M., Harrington, R. A., Braunwald, E., Mahaffey, K. W., & Newby, L. K. (2013). Cardiac troponin after percutaneous coronary intervention and 1-year mortality in Non-ST-segment elevation acute coronary syndrome using systematic evaluation of biomarker trends. Journal of the American College of Cardiology, 62(3), 242-251. https://doi.org/10.1016/j.jacc.2013.04.043