Abstract
Objective: To monitor cardiac troponin I (cTnl), a newly developed biochemical index for cardiac damage, in patients during and after coronary artery bypass surgery (CABS) to determine whether the measurement of the serum levels of this marker could be of value in formulating an early diagnosis of Q-wave perioperative myocardial infarction (PMI). Design: Prospective study with sequential measurements of biological markers in a selected surgical patient group. Setting: University research laboratory and general university hospital (Cardiac Surgery Unit and Anesthesiology and Reanimation Unit). Patients: Forty-two patients undergoing elective CABS without concomitant valvular replacement. Interventions: There were no interventions required for this study. However, patients entered into the study had CABS, sequential arterial blood samples, ECG recordings, and echocardiograms performed. Measurements and Main Results: Pre-, intra-, and postoperative (up to 48 hrs) measurements of cardiac troponin I, MB-CK, and total creatine kinase, as well as serial electrocardiograms and echocardiograms. Perioperative infarction was assessed as the development of new persistent regional wall motion abnormalities in echocardiography together with electrocardiographic alterations and MB-CK increases. Eight patients had Q-wave PMI. All PMI patients had elevated peak cTnl values (all >9.2 ng/mL), whereas the 34 nonPMI patients had peak values
| Original language | English |
|---|---|
| Pages (from-to) | 1986-1990 |
| Number of pages | 5 |
| Journal | Critical Care Medicine |
| Volume | 26 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Dec 1998 |
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Keywords
- Biological markers
- Coronary artery bypass
- Creatine kinase isoenzymes (MB form)
- Myocardial infarction
- Predictive value of tests
- Troponin
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Cardiac troponin I and Q-wave perioperative myocardial infarction after coronary artery bypass surgery. / Gensini, Gian Franco; Fusi, Costanza; Conti, Andrea A.; Calamai, Gian Carlo; Montesi, Gian Franco; Galanti, Giorgio; Noferi, Daniela; Carbonetto, Fiorella; Palmarini, Maria Fulvia; Abbate, Rosanna; Vaccari, Marino.
In: Critical Care Medicine, Vol. 26, No. 12, 12.1998, p. 1986-1990.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Cardiac troponin I and Q-wave perioperative myocardial infarction after coronary artery bypass surgery
AU - Gensini, Gian Franco
AU - Fusi, Costanza
AU - Conti, Andrea A.
AU - Calamai, Gian Carlo
AU - Montesi, Gian Franco
AU - Galanti, Giorgio
AU - Noferi, Daniela
AU - Carbonetto, Fiorella
AU - Palmarini, Maria Fulvia
AU - Abbate, Rosanna
AU - Vaccari, Marino
PY - 1998/12
Y1 - 1998/12
N2 - Objective: To monitor cardiac troponin I (cTnl), a newly developed biochemical index for cardiac damage, in patients during and after coronary artery bypass surgery (CABS) to determine whether the measurement of the serum levels of this marker could be of value in formulating an early diagnosis of Q-wave perioperative myocardial infarction (PMI). Design: Prospective study with sequential measurements of biological markers in a selected surgical patient group. Setting: University research laboratory and general university hospital (Cardiac Surgery Unit and Anesthesiology and Reanimation Unit). Patients: Forty-two patients undergoing elective CABS without concomitant valvular replacement. Interventions: There were no interventions required for this study. However, patients entered into the study had CABS, sequential arterial blood samples, ECG recordings, and echocardiograms performed. Measurements and Main Results: Pre-, intra-, and postoperative (up to 48 hrs) measurements of cardiac troponin I, MB-CK, and total creatine kinase, as well as serial electrocardiograms and echocardiograms. Perioperative infarction was assessed as the development of new persistent regional wall motion abnormalities in echocardiography together with electrocardiographic alterations and MB-CK increases. Eight patients had Q-wave PMI. All PMI patients had elevated peak cTnl values (all >9.2 ng/mL), whereas the 34 nonPMI patients had peak values
AB - Objective: To monitor cardiac troponin I (cTnl), a newly developed biochemical index for cardiac damage, in patients during and after coronary artery bypass surgery (CABS) to determine whether the measurement of the serum levels of this marker could be of value in formulating an early diagnosis of Q-wave perioperative myocardial infarction (PMI). Design: Prospective study with sequential measurements of biological markers in a selected surgical patient group. Setting: University research laboratory and general university hospital (Cardiac Surgery Unit and Anesthesiology and Reanimation Unit). Patients: Forty-two patients undergoing elective CABS without concomitant valvular replacement. Interventions: There were no interventions required for this study. However, patients entered into the study had CABS, sequential arterial blood samples, ECG recordings, and echocardiograms performed. Measurements and Main Results: Pre-, intra-, and postoperative (up to 48 hrs) measurements of cardiac troponin I, MB-CK, and total creatine kinase, as well as serial electrocardiograms and echocardiograms. Perioperative infarction was assessed as the development of new persistent regional wall motion abnormalities in echocardiography together with electrocardiographic alterations and MB-CK increases. Eight patients had Q-wave PMI. All PMI patients had elevated peak cTnl values (all >9.2 ng/mL), whereas the 34 nonPMI patients had peak values
KW - Biological markers
KW - Coronary artery bypass
KW - Creatine kinase isoenzymes (MB form)
KW - Myocardial infarction
KW - Predictive value of tests
KW - Troponin
UR - http://www.scopus.com/inward/record.url?scp=0032414994&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032414994&partnerID=8YFLogxK
U2 - 10.1097/00003246-199812000-00025
DO - 10.1097/00003246-199812000-00025
M3 - Article
C2 - 9875908
AN - SCOPUS:0032414994
VL - 26
SP - 1986
EP - 1990
JO - Critical Care Medicine
JF - Critical Care Medicine
SN - 0090-3493
IS - 12
ER -