Cardiac troponin I and Q-wave perioperative myocardial infarction after coronary artery bypass surgery

Gian Franco Gensini, Costanza Fusi, Andrea A. Conti, Gian Carlo Calamai, Gian Franco Montesi, Giorgio Galanti, Daniela Noferi, Fiorella Carbonetto, Maria Fulvia Palmarini, Rosanna Abbate, Marino Vaccari

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To monitor cardiac troponin I (cTnl), a newly developed biochemical index for cardiac damage, in patients during and after coronary artery bypass surgery (CABS) to determine whether the measurement of the serum levels of this marker could be of value in formulating an early diagnosis of Q-wave perioperative myocardial infarction (PMI). Design: Prospective study with sequential measurements of biological markers in a selected surgical patient group. Setting: University research laboratory and general university hospital (Cardiac Surgery Unit and Anesthesiology and Reanimation Unit). Patients: Forty-two patients undergoing elective CABS without concomitant valvular replacement. Interventions: There were no interventions required for this study. However, patients entered into the study had CABS, sequential arterial blood samples, ECG recordings, and echocardiograms performed. Measurements and Main Results: Pre-, intra-, and postoperative (up to 48 hrs) measurements of cardiac troponin I, MB-CK, and total creatine kinase, as well as serial electrocardiograms and echocardiograms. Perioperative infarction was assessed as the development of new persistent regional wall motion abnormalities in echocardiography together with electrocardiographic alterations and MB-CK increases. Eight patients had Q-wave PMI. All PMI patients had elevated peak cTnl values (all >9.2 ng/mL), whereas the 34 nonPMI patients had peak values

Original languageEnglish
Pages (from-to)1986-1990
Number of pages5
JournalCritical Care Medicine
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 1998

Keywords

  • Biological markers
  • Coronary artery bypass
  • Creatine kinase isoenzymes (MB form)
  • Myocardial infarction
  • Predictive value of tests
  • Troponin

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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