Cardio-respiratory autonomic responses to nociceptive stimuli in patients with disorders of consciousness

Research output: Contribution to journalArticle

Abstract

The autonomic response to pain might discriminate among consciousness disorders. Therefore, aim of this study was to describe differences between minimally conscious state (MCS) and unresponsive wakefulness syndrome (UWS) patients in their autonomic response to a nociceptive stimulus. ECG, respiration, finger blood pressure (BP) and total peripheral resistances (TPR) were continuously recorded before, during and after a standardized noxious stimulus in 20 adult brain-injured patients, 14 in UWS and 6 in MCS. Occurrence of fast autonomic responses synchronous with the stimulus was detected by visual inspection of the tracings; short-term (<20 s) and long-term (between 20s and 50 s from the stimulus) responses were evaluated by beat-by-beat quantitative analysis. The noxious stimulus elicited fast responses in both groups, but only MCS patients showed a significant short-term response in TPR and long-term response in HR. Thus, short- and long-term cardiovascular responses to pain might integrate neuro-behavioural assessments to discriminate between MCS and UWS.

Original languageEnglish
Article numbere0201921
JournalPLoS One
Volume13
Issue number9
DOIs
Publication statusPublished - Sep 1 2018

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consciousness disorders
Consciousness Disorders
Persistent Vegetative State
Blood pressure
Electrocardiography
Wakefulness
Brain
Inspection
pain
Chemical analysis
Vascular Resistance
Pain
breathing
blood pressure
quantitative analysis
Fingers
brain
Respiration
Blood Pressure

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Cardio-respiratory autonomic responses to nociceptive stimuli in patients with disorders of consciousness. / Devalle, Guya; Castiglioni, Paolo; Arienti, Chiara; Abbate, Carlo; Mazzucchi, Anna; Agnello, Luca; Merati, Giampiero.

In: PLoS One, Vol. 13, No. 9, e0201921, 01.09.2018.

Research output: Contribution to journalArticle

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AU - Agnello, Luca

AU - Merati, Giampiero

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