Cardiomyocyte ageing and cardioprotection. Consensus document from the ESC working groups cell biology of the heart and myocardial function

Marisol Ruiz-Meana, Diana Bou-Teen, Péter Ferdinandy, Mariann Gyongyosi, Maurizio Pesce, Cinzia Perrino, Rainer Schulz, Joost P.G. Sluijter, Carlo G. Tocchetti, Thomas Thum, Rosalinda Madonna

Research output: Contribution to journalReview articlepeer-review

Abstract

Advanced age is a major predisposing risk factor for the incidence of coronary syndromes and comorbid conditions which impact the heart response to cardioprotective interventions. Advanced age also significantly increases the risk of developing post-ischaemic adverse remodelling and heart failure after ischaemia/reperfusion (IR) injury. Some of the signalling pathways become defective or attenuated during ageing, whereas others with well-known detrimental consequences, such as glycoxidation or proinflammatory pathways, are exacerbated. The causative mechanisms responsible for all these changes are yet to be elucidated and are a matter of active research. Here, we review the current knowledge about the pathophysiology of cardiac ageing that eventually impacts on the increased susceptibility of cells to IR injury and can affect the efficiency of cardioprotective strategies.

Original languageEnglish
Pages (from-to)1835-1849
Number of pages15
JournalCardiovascular Research
Volume116
Issue number11
DOIs
Publication statusPublished - Sep 1 2020

Keywords

  • Animal models
  • Cardiac ageing
  • Cardioprotection
  • Ischaemia/reperfusion injury
  • Omics

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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