La cardioprotezione nelle donne con patologia oncologica

Translated title of the contribution: Cardioprotection in women with oncological disease

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiotoxicity (CTX) is a serious adverse effect of anticancer drugs that impacts on quality of life and overall survival of cancer patients. Hypokinetic cardiomyopathy is the most typical form of CTX, and it is traditionally considered refractory to therapy. Prevention of CTX remains of paramount importance, and several measures, including serial cardiac function monitoring, reduction of cumulative anthracycline dose, use of anthracycline analogues and cardioprotective agents, have been proposed. Over the last decade, however, a new approach based on cardiac biomarkers has emerged as an effective alternative strategy for the early detection of subclinical cardiac injury. In particular, the role of troponin I in identifying patients at risk of CTX as well as of angiotensin-converting enzyme inhibitors in preventing left ventricular dysfunction and late cardiac events in high-risk patients, namely those with raised troponin I levels after chemotherapy, has been consistently demonstrated as an effective tool for CTX prevention.

Translated title of the contributionCardioprotection in women with oncological disease
Original languageItalian
Pages (from-to)461-468
Number of pages8
JournalGiornale Italiano di Cardiologia
Volume13
Issue number6
DOIs
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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