Effetti cardioprotettivi della vitamina D nei pazienti con malattia renale cronica allo stadio 3-5 non in dialisi.

Translated title of the contribution: [Cardioprotective effect of vitamin D in nondialyzed patients with stage 3-5 CKD].

Mario Cozzolino, Florjan Mehmeti, Francesca Bonelli, Chiara Ronga, Claudio Musetti, Elena Missaglia, Andrea Stucchi, Francesca Colombo, Marta Tavecchia, Paola Cuoccio, Irene Brenna, Elisa Volpi, Paola Ciceri, Daniele Cusi

Research output: Contribution to journalArticlepeer-review

Abstract

Epidemiological and observational data indicate that there is a close relationship between progressive renal dysfunction in chronic kidney disease (CKD), cardiovascular disease, and mortality. In addition, deficits in vitamin D (25-hydroxyvitamin D) and vitamin D receptor (VDR) activation play a crucial role in adversely affecting cardiovascular health in CKD patients. Even in patients with mild CKD, renal dysfunction is associated with cardiovascular events. Modulation of vitamin D levels results in correlative regulatory effects on mineral homeostasis, hypertension, and vascular calcification. The use of VDR activators such as paricalcitol to treat these and other parameters outside of cardiovascular and renal disease not only results in enhanced patient health but significantly reduces the mortality risk in CKD patients.

Translated title of the contribution[Cardioprotective effect of vitamin D in nondialyzed patients with stage 3-5 CKD].
Original languageItalian
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume27 Suppl 52
Publication statusPublished - Nov 2010

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of '[Cardioprotective effect of vitamin D in nondialyzed patients with stage 3-5 CKD].'. Together they form a unique fingerprint.

Cite this