Cardiopulmonary bypass and oxygen consumption: Oxygen delivery and hemodynamics

Alessandro Parolari, Francesco Alamanni, Tiziano Gherli, Antonella Bertera, Luca Dainese, Cristina Costa, Mara Schena, Erminio Sisillo, Rita Spirito, Massimo Porqueddu, Paolo Rona, Paolo Biglioli

Research output: Contribution to journalArticle


Background. This study was undertaken to investigate the relations between whole body oxygen consumption (VO2), oxygen delivery (DO2), and hemodynamic variables during cardiopulmonary bypass. Methods. One hundred one patients were studied during cooling, hypothermia, and rewarming. Oxygen consumption, DO2, hemodynamics, and DO(2crit) were measured at these times. Results. There was a direct linear relation between DO2 and VO2 during all three times. No relation between VO2 and hemodynamics was detected during cooling; during hypothermia, an inverse linear relation with peripheral arterial resistance was found. Finally, during rewarming, there was a direct relation with pump flow rate, and an inverse relation with arterial pressure and arterial resistance. The same relations among the variables were found at delivery levels above or below DO(2crit). Conclusions. During cardiopulmonary bypass there is a direct linear relation between DO2 and VO2; the relations with hemodynamic variables depend on the phases of cardiopulmonary bypass. This suggests that increasing delivery levels may recruit and perfuse more vascular beds, and higher delivery levels are advisable during perfusion. During rewarming and hypothermia, lower arterial resistances are also desirable to optimize VO2.

Original languageEnglish
Pages (from-to)1320-1327
Number of pages8
JournalAnnals of Thoracic Surgery
Issue number5
Publication statusPublished - May 1 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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    Parolari, A., Alamanni, F., Gherli, T., Bertera, A., Dainese, L., Costa, C., Schena, M., Sisillo, E., Spirito, R., Porqueddu, M., Rona, P., & Biglioli, P. (1999). Cardiopulmonary bypass and oxygen consumption: Oxygen delivery and hemodynamics. Annals of Thoracic Surgery, 67(5), 1320-1327.