Cardiopulmonary bypass in patients with heparin-induced thrombocytopenia and thrombosis

Fabrizio Follis, Carlos A. Schmidt

Research output: Contribution to journalArticlepeer-review


Heparin-induced thrombocytopenia and thrombosis (HITT) is an immunomediated disorder induced by the administration of heparin for therapeutic purposes. The presence of this condition in patients requiring full heparinization for cardiopulmonary bypass constitutes a formidable challenge for the cardiac surgeon. In this review, the clinical and experimental experience described in the literature are discussed in the perspective of the normal coagulation and the pathophysiology of HITT and in the light of a variety of old and new alternative anticoagulants.

Original languageEnglish
Pages (from-to)2173-2181
Number of pages9
JournalAnnals of Thoracic Surgery
Issue number6
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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