Cardiopulmonary bypass increases plasma bradykinin concentrations

M. Cugno, J. Nussberger, P. Biglioli, M. G. Giovagnoni, M. Gardinali, A. Agostoni

Research output: Contribution to journalArticlepeer-review


An increase of bradykinin (BK) plasma levels together with the activation coagulation cascade, fibrinolysis, complement and cytokines was observed during cardiopulmonary bypass (CPB). Since the procedure of extracorporeal circulation completely excludes the lung, the major site of BK catabolism, our data suggest that a reduced catabolism could contribute to the increase of BK during CPB. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)145-147
Number of pages3
Issue number2-3
Publication statusPublished - Sep 1999


  • Bradykinin
  • Cardiopulmonary bypass
  • Catabolism

ASJC Scopus subject areas

  • Pharmacology

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