Cardiopulmonary bypass increases plasma bradykinin concentrations

M. Cugno; J. Nussberger; P. Biglioli; M. G. Giovagnoni; M. Gardinali; A. Agostoni

doi:10.1016/S0162-3109(99)00072-7

Cardiopulmonary bypass increases plasma bradykinin concentrations

M. Cugno, J. Nussberger, P. Biglioli, M. G. Giovagnoni, M. Gardinali, A. Agostoni

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

An increase of bradykinin (BK) plasma levels together with the activation coagulation cascade, fibrinolysis, complement and cytokines was observed during cardiopulmonary bypass (CPB). Since the procedure of extracorporeal circulation completely excludes the lung, the major site of BK catabolism, our data suggest that a reduced catabolism could contribute to the increase of BK during CPB. Copyright (C) 1999 Elsevier Science B.V.

Original language	English
Pages (from-to)	145-147
Number of pages	3
Journal	Immunopharmacology
Volume	43
Issue number	2-3
DOIs	https://doi.org/10.1016/S0162-3109(99)00072-7
Publication status	Published - Sep 1999

Keywords

Bradykinin
Cardiopulmonary bypass
Catabolism

ASJC Scopus subject areas

Pharmacology

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10.1016/S0162-3109(99)00072-7

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AU - Nussberger, J.

AU - Biglioli, P.

AU - Giovagnoni, M. G.

AU - Gardinali, M.

AU - Agostoni, A.

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AB - An increase of bradykinin (BK) plasma levels together with the activation coagulation cascade, fibrinolysis, complement and cytokines was observed during cardiopulmonary bypass (CPB). Since the procedure of extracorporeal circulation completely excludes the lung, the major site of BK catabolism, our data suggest that a reduced catabolism could contribute to the increase of BK during CPB. Copyright (C) 1999 Elsevier Science B.V.

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KW - Catabolism

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