Cardiopulmonary exercise testing as a diagnostic tool for the detection of left-sided pulmonary hypertension in heart failure.

Marco Guazzi, Lawrence P. Cahalin, Ross Arena

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Recently, it has become increasingly recognized that pulmonary hypertension (PH) is a particularly ominous consequence of left-sided heart failure (HF). The primary aim of this investigation was to assess the ability of key cardiopulmonary exercise testing (CPX) variables to detect elevated pulmonary pressures in a HF cohort. This was a retrospective analysis of a prospectively collected database. Two hundred ninety-three subjects with HF (63 ± 10 years old, 79% male) underwent Doppler echocardiography to estimate resting pulmonary artery systolic pressure (PASP). Peak oxygen consumption (VO2), the minute ventilation/carbon dioxide production (VE/VCO2) slope, peak partial pressure of end-tidal CO2 (PETCO2) and exercise oscillatory ventilation (EOV) were determined. Forty-six percent (n = 134) of the subjects presented with a PASP ≥ 40 mm Hg. A VE/VCO2 slope

Original languageEnglish
Pages (from-to)461-467
Number of pages7
JournalJournal of Cardiac Failure
Issue number7
Publication statusPublished - Jul 2013


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Medicine(all)

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