Cardiopulmonary exercise testing in the assessment of pulmonary hypertension

Ross Arena, Marco Guazzi, Jonathan Myers, Daniel Grinnen, Daniel E. Forman, Carl J. Lavie

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The assessment of patients with suspected or confirmed pulmonary arterial hypertension (PAH) and secondary pulmonary hypertension (PH) continues to evolve and, in recent years, evidence demonstrating that cardiopulmonary exercise testing (CPX) provides valuable information has grown at an impressive rate. The key premise supporting the use of CPX is that certain variables obtained provide insight into the degree of ventilation/perfusion mismatching secondary to altered pulmonary hemodynamics. In this article, we discuss the pathophysiology of PAH and secondary PH and its impact on cardiac function, review the clinical presentation of patients with elevated pulmonary pressures and outline a case for the use of CPX as an integral assessment technique, discuss CPX technology and testing procedures, and review the current state of available evidence and provide clinical recommendations for CPX in the setting of known or suspected PAH and secondary PH.

Original languageEnglish
Pages (from-to)281-293
Number of pages13
JournalExpert Review of Respiratory Medicine
Volume5
Issue number2
DOIs
Publication statusPublished - Apr 2011

Fingerprint

Pulmonary Hypertension
Exercise
Lung
Ventilation
Perfusion
Hemodynamics
Technology
Pressure

Keywords

  • aerobic capacity
  • carbon dioxide production
  • diagnosis
  • minute ventilation
  • prognosis
  • pulmonary vasculopathy
  • ventilatory efficiency

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Public Health, Environmental and Occupational Health

Cite this

Cardiopulmonary exercise testing in the assessment of pulmonary hypertension. / Arena, Ross; Guazzi, Marco; Myers, Jonathan; Grinnen, Daniel; Forman, Daniel E.; Lavie, Carl J.

In: Expert Review of Respiratory Medicine, Vol. 5, No. 2, 04.2011, p. 281-293.

Research output: Contribution to journalArticle

Arena, Ross ; Guazzi, Marco ; Myers, Jonathan ; Grinnen, Daniel ; Forman, Daniel E. ; Lavie, Carl J. / Cardiopulmonary exercise testing in the assessment of pulmonary hypertension. In: Expert Review of Respiratory Medicine. 2011 ; Vol. 5, No. 2. pp. 281-293.
@article{acb59e0d80f24aea8f02c5e06e63ce5c,
title = "Cardiopulmonary exercise testing in the assessment of pulmonary hypertension",
abstract = "The assessment of patients with suspected or confirmed pulmonary arterial hypertension (PAH) and secondary pulmonary hypertension (PH) continues to evolve and, in recent years, evidence demonstrating that cardiopulmonary exercise testing (CPX) provides valuable information has grown at an impressive rate. The key premise supporting the use of CPX is that certain variables obtained provide insight into the degree of ventilation/perfusion mismatching secondary to altered pulmonary hemodynamics. In this article, we discuss the pathophysiology of PAH and secondary PH and its impact on cardiac function, review the clinical presentation of patients with elevated pulmonary pressures and outline a case for the use of CPX as an integral assessment technique, discuss CPX technology and testing procedures, and review the current state of available evidence and provide clinical recommendations for CPX in the setting of known or suspected PAH and secondary PH.",
keywords = "aerobic capacity, carbon dioxide production, diagnosis, minute ventilation, prognosis, pulmonary vasculopathy, ventilatory efficiency",
author = "Ross Arena and Marco Guazzi and Jonathan Myers and Daniel Grinnen and Forman, {Daniel E.} and Lavie, {Carl J.}",
year = "2011",
month = "4",
doi = "10.1586/ers.11.4",
language = "English",
volume = "5",
pages = "281--293",
journal = "Expert Review of Respiratory Medicine",
issn = "1747-6348",
publisher = "Expert Reviews Ltd.",
number = "2",

}

TY - JOUR

T1 - Cardiopulmonary exercise testing in the assessment of pulmonary hypertension

AU - Arena, Ross

AU - Guazzi, Marco

AU - Myers, Jonathan

AU - Grinnen, Daniel

AU - Forman, Daniel E.

AU - Lavie, Carl J.

PY - 2011/4

Y1 - 2011/4

N2 - The assessment of patients with suspected or confirmed pulmonary arterial hypertension (PAH) and secondary pulmonary hypertension (PH) continues to evolve and, in recent years, evidence demonstrating that cardiopulmonary exercise testing (CPX) provides valuable information has grown at an impressive rate. The key premise supporting the use of CPX is that certain variables obtained provide insight into the degree of ventilation/perfusion mismatching secondary to altered pulmonary hemodynamics. In this article, we discuss the pathophysiology of PAH and secondary PH and its impact on cardiac function, review the clinical presentation of patients with elevated pulmonary pressures and outline a case for the use of CPX as an integral assessment technique, discuss CPX technology and testing procedures, and review the current state of available evidence and provide clinical recommendations for CPX in the setting of known or suspected PAH and secondary PH.

AB - The assessment of patients with suspected or confirmed pulmonary arterial hypertension (PAH) and secondary pulmonary hypertension (PH) continues to evolve and, in recent years, evidence demonstrating that cardiopulmonary exercise testing (CPX) provides valuable information has grown at an impressive rate. The key premise supporting the use of CPX is that certain variables obtained provide insight into the degree of ventilation/perfusion mismatching secondary to altered pulmonary hemodynamics. In this article, we discuss the pathophysiology of PAH and secondary PH and its impact on cardiac function, review the clinical presentation of patients with elevated pulmonary pressures and outline a case for the use of CPX as an integral assessment technique, discuss CPX technology and testing procedures, and review the current state of available evidence and provide clinical recommendations for CPX in the setting of known or suspected PAH and secondary PH.

KW - aerobic capacity

KW - carbon dioxide production

KW - diagnosis

KW - minute ventilation

KW - prognosis

KW - pulmonary vasculopathy

KW - ventilatory efficiency

UR - http://www.scopus.com/inward/record.url?scp=79955379475&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955379475&partnerID=8YFLogxK

U2 - 10.1586/ers.11.4

DO - 10.1586/ers.11.4

M3 - Article

VL - 5

SP - 281

EP - 293

JO - Expert Review of Respiratory Medicine

JF - Expert Review of Respiratory Medicine

SN - 1747-6348

IS - 2

ER -