Cardiopulmonary receptor and arterial baroreceptor reflexes after acute myocardial infarction

Guido Grassi, Cristina Giannattasio, Gino Seravalle, Giuseppe Osculati, Franco Valagussa, Alberto Zanchetti, Giuseppe Mancia

Research output: Contribution to journalArticlepeer-review


The baroreceptor-heart rate reflex in human is impaired 2 days after a myocardial infarction but it improves 10 days after the acute coronary event. This study investigated whether (1) the baroreceptor-heart rate reflex improvement takes the reflex back to normal, and (2) the cardiopulmonary reflex is affected by myocardial infarction. In subjects studied 8 to 11 days after a transmural anterior or inferior myocardial infarction the baroreceptor-heart rate reflex sensitivity (slope of the linear regression between negative neck chamber pressures and lengthenings in RR interval) was similar to that seen in control subjects (-6.2 ± 0.8 vs -6.0 ± 0.6 ms/mm Hg, mean ± SEM) and did not change when reassessed 10 days later. In contrast, the cardiopulmonary reflex sensitivity (changes in forearm vascular resistance induced by changing central venous pressure through nonhypotensive lower body suction and leg raising) was markedly less in subjects studied 8 to 11 days after myocardial infarction than in control subjects; the reduction amounted to 58.1 ± 8% (p <0.01). The cardiopulmonary reflex sensitivity greatly improved when reassessed 28 to 45 days later. Thus, the baroreflex is normal about 10 days after myocardial infarction. This condition markedly impairs the cardiopulmonary reflex, but the impairment is also transient.

Original languageEnglish
Pages (from-to)873-878
Number of pages6
JournalThe American Journal of Cardiology
Issue number9
Publication statusPublished - Apr 1 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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