Cardiorespiratory functional assessment after pediatric heart transplantation

Enrica Pastore, Attilio Turchetta, Leonello Attias, Armando Calzolari, Ugo Giordano, Cosimo Squitieri, Francesco Parisi

Research output: Contribution to journalArticle


Limited data are available on the exercise capacity of young heart transplant recipients. The aim of this study was therefore to assess cardiorespiratory responses to exercise in this group of patients. Fourteen consecutive heart transplant recipients (six girls and eight boys, age-range 5-15 yr) and 14 healthy matched controls underwent a Bruce treadmill test to determine: duration of test; resting and maximum heart rates; maximum systolic blood pressure; peak oxygen consumption (VO2peak); and cardiac output. Duration of test and heart rate increase were then compared with: time since transplantation, rejections per year, and immunosuppressive drugs received. The recipients also underwent the following lung function tests: forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). When compared with healthy controls, transplant recipients had tachycardia at rest (126±3.7 beats/min; p2 peak. The heart-rate increase correlated significantly with time post-transplant (r=0.55; p1 values. After surgery, few heart transplant recipients undertake physical activity, possibly owing to over-protective parents and teachers and to a lack of suitable supervised facilities. The authors stress the importance of a cardiorespiratory functional evaluation for assessment of health status and to encourage recipients, if possible, to undertake regular physical activity.

Original languageEnglish
Pages (from-to)425-429
Number of pages5
JournalPediatric Transplantation
Issue number6
Publication statusPublished - 2001



  • Children
  • Exercise testing
  • Heart transplantation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

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