Cardiorespiratory interactions during periodic breathing in awake chronic heart failure patients

Research output: Contribution to journalArticlepeer-review

Abstract

We applied spectral techniques to the analysis of cardiorespiratory signals [instantaneous lung volume (ILV), instantaneous tidal volume (ITV), arterial O2 saturation (Sa(O2)) at the ear, heart rate (HR), systolic (SAP), and diastolic (DAP) arterial pressure] during nonapneic periodic breathing (PB) in 29 awake chronic heart failure (CHF) patients and estimated the timing relationships between respiratory and slow cardiovascular (2) was highly coherent with (coherence function = 0.96 ± 0.009) and almost opposite in phase to ITV. These findings demonstrate the existence of a generalized cardiorespiratory rhythm led by the ventilatory oscillation and suggest that 1) the cyclic increase in inspiratory drive and cardiopulmonary reflexes and 2) mechanical effects of PB-induced changes in intrathoracic pressure are the more likely sources of the HR and blood pressure oscillations, respectively. The timing relationship between ITV and blood pressure signals excludes the possibility that PB represents the effect of a central vasomotor rhythm.

Original languageEnglish
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume278
Issue number3 47-3
Publication statusPublished - Mar 2000

Keywords

  • Cardiopulmonary receptors
  • Cardiovascular variability
  • Chemoreceptors
  • Spectral analysis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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