Cardiospheres and tissue engineering for myocardial regeneration: Potential for clinical application

Roberto Gaetani, Giuseppe Rizzitelli, Isotta Chimenti, Lucio Barile, Elvira Forte, Vittoria Ionta, Francesco Angelini, Joost P G Sluijter, Andrea Barbetta, Elisa Messina, Giacomo Frati

Research output: Contribution to journalArticlepeer-review

Abstract

Tissue engineering is an increasingly expanding area of research in the cardiovascular field that involves engineering, chemistry, biology and medicine. Cardiac tissue engineering (CTE) aims to regenerate myocardial damage by combining cells, matrix, biological active molecules and physiological stimuli. The rationale behind CTE applications is that in order to regenerate the ventricular wall after a myocardial infarction it is necessary to combine procedures that regenerate both cardiomyocytes and the extracellular matrix. The application of (stem) cells together with a matrix could represent an environment protected from the inflammatory and pro-apoptotic signals, a stemness/survival reservoir slowly releasing cells and factors promoting tissue regeneration and angiogenesis. This review will focus on the applications and advantages that CTE application could offer compared to conventional cell therapy.

Original languageEnglish
Pages (from-to)1071-1077
Number of pages7
JournalJournal of Cellular and Molecular Medicine
Volume14
Issue number5
DOIs
Publication statusPublished - 2010

Keywords

  • Cardiac progenitor cells
  • Cardiac regeneration
  • Cardiac tissue engineering
  • Cardiospheres
  • Cell therapy

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Medicine(all)

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