Cardiotoxicity after low-dose chloroquine antimalarial therapy

Gabriele Fragasso, Francesca Sanvito, Francesca Baratto, Sabina Martinenghi, Claudio Doglioni, Alberto Margonato

Research output: Contribution to journalArticle

Abstract

Previous reports on antimalarial toxicity have only been related to long-term continuous treatments for nonmalarial indications, which require prolonged use of large doses, up to 1000 g or more every year. We describe a patient with recurrent malaria, prophylactically treated with low-dose chloroquine, who developed heart failure due to biventricular cardiac dysfunction. The right ventricle endomyocardial biopsy was suggestive of chloroquine toxicity. The heart failure improved after drug withdrawal. As a consequence, the potential for reversibility and the severity in undiagnosed cases of these toxic cardiomyopathies emphasize the importance of recognizing early signs of toxicity in order to withdraw antimalarials before the occurrence of life-threatening cardiac toxicity.

Original languageEnglish
Pages (from-to)385-387
Number of pages3
JournalHeart and Vessels
Volume24
Issue number5
DOIs
Publication statusPublished - 2009

Keywords

  • Cardiomyopathy
  • Chloroquine
  • Endomyocardial biopsy
  • Heart failure
  • Toxicity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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