TY - JOUR
T1 - Cardiovascular abnormalities in Klinefelter syndrome
AU - Pasquali, Daniela
AU - Arcopinto, Michele
AU - Renzullo, Andrea
AU - Rotondi, Mario
AU - Accardo, Giacomo
AU - Salzano, Andrea
AU - Esposito, Daniela
AU - Saldamarco, Lavinia
AU - Isidori, Andrea M.
AU - Marra, Alberto M.
AU - Ruvolo, Antonio
AU - Napoli, Raffaele
AU - Bossone, Eduardo
AU - Lenzi, Andrea
AU - Baliga, Ragavendra R.
AU - Saccà, Luigi
AU - Cittadini, Antonio
PY - 2013/9/30
Y1 - 2013/9/30
N2 - Background: Several epidemiological studies have demonstrated an increased mortality from cardiovascular causes in patients with Klinefelter Syndrome (KS). Little information is available about the nature of the underlying cardiovascular abnormalities. Aim of the study was to investigate exercise performance, left ventricular architecture and function, vascular reactivity, and carotid intima-media thickness in a group of patients with KS. Materials and methods: Sixty-nine patients with KS and 48 age-matched controls participated in our population-controlled study. Forty-eight Klinefelter subjects were on testosterone treatment at the time of the investigation while 21 were naive and underwent a complete Doppler echocardiographic examination, a cardiopulmonary exercise test as well as a vascular study including measures of carotid intima-media thickness and endothelial function with flow-mediated dilation of the brachial artery. Patientswith KS on testosterone therapy (n=48) were also matched against a population of men with treated secondary hypogonadism (n=21). Results: Patients with KS exhibited a wide array of cardiovascular abnormalities including left ventricular diastolic dysfunction, reducedmaximal oxygen consumption (p
AB - Background: Several epidemiological studies have demonstrated an increased mortality from cardiovascular causes in patients with Klinefelter Syndrome (KS). Little information is available about the nature of the underlying cardiovascular abnormalities. Aim of the study was to investigate exercise performance, left ventricular architecture and function, vascular reactivity, and carotid intima-media thickness in a group of patients with KS. Materials and methods: Sixty-nine patients with KS and 48 age-matched controls participated in our population-controlled study. Forty-eight Klinefelter subjects were on testosterone treatment at the time of the investigation while 21 were naive and underwent a complete Doppler echocardiographic examination, a cardiopulmonary exercise test as well as a vascular study including measures of carotid intima-media thickness and endothelial function with flow-mediated dilation of the brachial artery. Patientswith KS on testosterone therapy (n=48) were also matched against a population of men with treated secondary hypogonadism (n=21). Results: Patients with KS exhibited a wide array of cardiovascular abnormalities including left ventricular diastolic dysfunction, reducedmaximal oxygen consumption (p
KW - Cardiovascular abnormalities
KW - Chronotropic incompetence
KW - Heart
KW - Klinefelter
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U2 - 10.1016/j.ijcard.2012.09.215
DO - 10.1016/j.ijcard.2012.09.215
M3 - Article
C2 - 23092857
AN - SCOPUS:84885316766
VL - 168
SP - 754
EP - 759
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 2
ER -