Cardiovascular abnormalities in Klinefelter syndrome

Daniela Pasquali, Michele Arcopinto, Andrea Renzullo, Mario Rotondi, Giacomo Accardo, Andrea Salzano, Daniela Esposito, Lavinia Saldamarco, Andrea M. Isidori, Alberto M. Marra, Antonio Ruvolo, Raffaele Napoli, Eduardo Bossone, Andrea Lenzi, Ragavendra R. Baliga, Luigi Saccà, Antonio Cittadini

Research output: Contribution to journalArticlepeer-review


Background: Several epidemiological studies have demonstrated an increased mortality from cardiovascular causes in patients with Klinefelter Syndrome (KS). Little information is available about the nature of the underlying cardiovascular abnormalities. Aim of the study was to investigate exercise performance, left ventricular architecture and function, vascular reactivity, and carotid intima-media thickness in a group of patients with KS. Materials and methods: Sixty-nine patients with KS and 48 age-matched controls participated in our population-controlled study. Forty-eight Klinefelter subjects were on testosterone treatment at the time of the investigation while 21 were naive and underwent a complete Doppler echocardiographic examination, a cardiopulmonary exercise test as well as a vascular study including measures of carotid intima-media thickness and endothelial function with flow-mediated dilation of the brachial artery. Patientswith KS on testosterone therapy (n=48) were also matched against a population of men with treated secondary hypogonadism (n=21). Results: Patients with KS exhibited a wide array of cardiovascular abnormalities including left ventricular diastolic dysfunction, reducedmaximal oxygen consumption (p

Original languageEnglish
Pages (from-to)754-759
Number of pages6
JournalInternational Journal of Cardiology
Issue number2
Publication statusPublished - Sep 30 2013


  • Cardiovascular abnormalities
  • Chronotropic incompetence
  • Heart
  • Klinefelter

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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