Abstract
Advanced liver disease is characterized by decreased arterial blood pressure and peripheral vascular resistances, increased cardiac output and heart rate in the setting of a hyperdynamic circulatory pattern favoured by total blood volume expansion, circulatory overload and overactivity of the endogenous vasoactive systems. Reduced heart responses to stressful conditions such as changes in loading conditions of the heart in presence of further deterioration of liver function such as refractory ascites, hepatorenal syndrome, spontaneous bacterial peritonitis and bleeding esophageal varices have been recently identified and the knowledge of the cirrhotic cardiomyopathy syndrome has gained the dignity of a new clinical entity. Facing the availability of therapeutic interventions (paracentesis, transjugular intrahepatic portosystemic shunt, peritoneovenous shunt, orthotopic liver transplantation) currently employed to manage the life-threatening complications of the most advanced phases of cirrhotic disease, the knowledge of their impact on cardiovascular function is of paramount relevance.
| Original language | English |
|---|---|
| Pages (from-to) | 263-272 |
| Number of pages | 10 |
| Journal | Gastroenterologia y Hepatologia |
| Volume | 29 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 2006 |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Cardiovascular abnormalities in special conditions of advanced cirrhosis. The circulatory adaptative changes to specific therapeutic procedures for the management of refractory ascites. / Pozzi, M.; Ratti, L.; Redaelli, E.; Guidi, C.; Mancia, G.
In: Gastroenterologia y Hepatologia, Vol. 29, No. 4, 01.2006, p. 263-272.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Cardiovascular abnormalities in special conditions of advanced cirrhosis. The circulatory adaptative changes to specific therapeutic procedures for the management of refractory ascites
AU - Pozzi, M.
AU - Ratti, L.
AU - Redaelli, E.
AU - Guidi, C.
AU - Mancia, G.
PY - 2006/1
Y1 - 2006/1
N2 - Advanced liver disease is characterized by decreased arterial blood pressure and peripheral vascular resistances, increased cardiac output and heart rate in the setting of a hyperdynamic circulatory pattern favoured by total blood volume expansion, circulatory overload and overactivity of the endogenous vasoactive systems. Reduced heart responses to stressful conditions such as changes in loading conditions of the heart in presence of further deterioration of liver function such as refractory ascites, hepatorenal syndrome, spontaneous bacterial peritonitis and bleeding esophageal varices have been recently identified and the knowledge of the cirrhotic cardiomyopathy syndrome has gained the dignity of a new clinical entity. Facing the availability of therapeutic interventions (paracentesis, transjugular intrahepatic portosystemic shunt, peritoneovenous shunt, orthotopic liver transplantation) currently employed to manage the life-threatening complications of the most advanced phases of cirrhotic disease, the knowledge of their impact on cardiovascular function is of paramount relevance.
AB - Advanced liver disease is characterized by decreased arterial blood pressure and peripheral vascular resistances, increased cardiac output and heart rate in the setting of a hyperdynamic circulatory pattern favoured by total blood volume expansion, circulatory overload and overactivity of the endogenous vasoactive systems. Reduced heart responses to stressful conditions such as changes in loading conditions of the heart in presence of further deterioration of liver function such as refractory ascites, hepatorenal syndrome, spontaneous bacterial peritonitis and bleeding esophageal varices have been recently identified and the knowledge of the cirrhotic cardiomyopathy syndrome has gained the dignity of a new clinical entity. Facing the availability of therapeutic interventions (paracentesis, transjugular intrahepatic portosystemic shunt, peritoneovenous shunt, orthotopic liver transplantation) currently employed to manage the life-threatening complications of the most advanced phases of cirrhotic disease, the knowledge of their impact on cardiovascular function is of paramount relevance.
UR - http://www.scopus.com/inward/record.url?scp=33646240141&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646240141&partnerID=8YFLogxK
U2 - 10.1157/13086820
DO - 10.1157/13086820
M3 - Article
C2 - 16584698
AN - SCOPUS:33646240141
VL - 29
SP - 263
EP - 272
JO - Gastroenterologia y Hepatologia
JF - Gastroenterologia y Hepatologia
SN - 0210-5705
IS - 4
ER -