Cardiovascular abnormalities in special conditions of advanced cirrhosis. The circulatory adaptative changes to specific therapeutic procedures for the management of refractory ascites

M. Pozzi, L. Ratti, E. Redaelli, C. Guidi, G. Mancia

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Advanced liver disease is characterized by decreased arterial blood pressure and peripheral vascular resistances, increased cardiac output and heart rate in the setting of a hyperdynamic circulatory pattern favoured by total blood volume expansion, circulatory overload and overactivity of the endogenous vasoactive systems. Reduced heart responses to stressful conditions such as changes in loading conditions of the heart in presence of further deterioration of liver function such as refractory ascites, hepatorenal syndrome, spontaneous bacterial peritonitis and bleeding esophageal varices have been recently identified and the knowledge of the cirrhotic cardiomyopathy syndrome has gained the dignity of a new clinical entity. Facing the availability of therapeutic interventions (paracentesis, transjugular intrahepatic portosystemic shunt, peritoneovenous shunt, orthotopic liver transplantation) currently employed to manage the life-threatening complications of the most advanced phases of cirrhotic disease, the knowledge of their impact on cardiovascular function is of paramount relevance.

Original languageEnglish
Pages (from-to)263-272
Number of pages10
JournalGastroenterologia y Hepatologia
Volume29
Issue number4
DOIs
Publication statusPublished - Jan 2006

Fingerprint

Cardiovascular Abnormalities
Ascites
Vascular Resistance
Fibrosis
Peritoneovenous Shunt
Hepatorenal Syndrome
Transjugular Intrahepatic Portasystemic Shunt
Paracentesis
Esophageal and Gastric Varices
Blood Volume
Peritonitis
Cardiomyopathies
Cardiac Output
Liver Transplantation
Liver Diseases
Arterial Pressure
Heart Rate
Hemorrhage
Liver
Therapeutics

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Cardiovascular abnormalities in special conditions of advanced cirrhosis. The circulatory adaptative changes to specific therapeutic procedures for the management of refractory ascites. / Pozzi, M.; Ratti, L.; Redaelli, E.; Guidi, C.; Mancia, G.

In: Gastroenterologia y Hepatologia, Vol. 29, No. 4, 01.2006, p. 263-272.

Research output: Contribution to journalArticle

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