Cardiovascular alterations in adult GH deficiency

C. Di Somma, E. Scarano, S. Savastano, M.C. Savanelli, R. Pivonello, A. Colao

Research output: Contribution to journalArticlepeer-review


There is a growing body of evidence indicating that patients with adult GH deficiency (GHD) are characterized by a cluster of traditional and emerging cardiovascular risk factors and markers, which can significantly increase their cardiovascular morbidity and mortality possibly linked to aberrations in GH status. Patients with adult GHD present multiple different cardiovascular abnormalities. In addition, cardiovascular risk in adult GHD is increased due to altered body composition, abnormal lipid profile, insulin resistance and impaired glucose metabolism. Cardiovascular risk factors can be reversed, at least partially, after GH replacement. However, evidence on the effects of GH replacement on cardiovascular events and mortality is too limited in adult GHD patients. Aim of this review is to provide an at-a-glance overview of the role of the GH/IGF-I on the cardiovascular system and the state of art of the effects of GH replacement on cardiovascular system. © 2017
Original languageEnglish
Pages (from-to)25-34
Number of pages10
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number1
Publication statusPublished - Mar 30 2017


  • body composition
  • cardiovascular system
  • GH replacement therapy
  • growth hormone
  • lipid profile
  • somatomedin C
  • biological marker
  • human growth hormone
  • adult
  • cardiovascular disease
  • cardiovascular risk
  • drug effect
  • growth hormone deficiency
  • hormone action
  • hormone substitution
  • human
  • Review
  • carbohydrate metabolism
  • deficiency
  • female
  • insulin resistance
  • male
  • physiology
  • risk factor
  • Adult
  • Biomarkers
  • Body Composition
  • Carbohydrate Metabolism
  • Cardiovascular Diseases
  • Female
  • Hormone Replacement Therapy
  • Human Growth Hormone
  • Humans
  • Insulin Resistance
  • Insulin-Like Growth Factor I
  • Male
  • Risk Factors


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