Cardiovascular and pulmonary activity of platelet-activating factor (PAF-Acether) and its derivatives

F. Berti, V. Ferri, M. Pallavicini, M. Pretolani, E. Tremoli, E. Valoti, L. Villa

Research output: Contribution to journalArticle

Abstract

Stereoselective synthesis and biological properties of PAF-acether, its enantiomer and some analogues of both are reported. The results clearly indicate that the ONIUM SIZE and SHAPE of the various compounds tested are important in determining guinea-pig bronchoconstriction and human platelet aggregation.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalPharmacological Research Communications
Volume18
Issue number6
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Pharmacology

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