Cardiovascular and thrombophilic risk factors for central retinal vein occlusion

Domenico Prisco, Rossella Marcucci, Laura Bertini, Anna Maria Gori

Research output: Contribution to journalArticlepeer-review


Retinal vein occlusion (RVO) is a relatively common disease that is often associated with a variety of systemic disorders including arterial hypertension, diabetes mellitus, dyslipidemia, and systemic vasculitis. There are various types of RVO, categorized on the basis of the site of occlusion and on the type of consequent vascular damage. Central retinal vein occlusion (CRVO) is the most frequently occurring and clinically relevant type of RVO. In addition to the well-known classical risk factors, new hemostasis-related ones have been investigated in patients affected by CRVO. The data concerning a number of parameters remain contradictory; yet, high levels of type 1 plasminogen activator inhibitor (PAI-1) and hyperhomocysteinemia appear to play a significant role in the pathogenesis of this disease. Although based on a limited number of studies, this new knowledge could eventually provide important indications regarding prognosis and therapeutic strategies.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalEuropean Journal of Internal Medicine
Issue number3
Publication statusPublished - 2002


  • Retinal vein occlusion
  • Risk factors
  • Thrombosis

ASJC Scopus subject areas

  • Medicine(all)
  • Internal Medicine


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