Cardiovascular autonomic control in myotonic dystrophy type 1: A correlative study with clinical and genetic data

Rita Di Leo, Carmelo Rodolico, Cesare De Gregorio, Antonino Recupero, Sebastiano Coglitore, Grazia Annesi, Antonio Toscano, Corrado Messina, Giuseppe Vita

Research output: Contribution to journalArticlepeer-review

Abstract

The autonomic nervous system has been evaluated in myotonic dystrophy with contradictory results and its relationship with heart disturbances remains unclear. Twenty-three patients with myotonic dystrophy type 1 were investigated by a battery of six cardiovascular autonomic tests and power spectral analysis of heart rate variability. Although 15 patients (65%) revealed abnormal or borderline results in some tests, only one patient had a definite autonomic damage, as indicated by two or more abnormal tests. As a group, myotonic dystrophy type 1 patients showed a significant reduction of heart rate variability during deep breathing (P

Original languageEnglish
Pages (from-to)136-141
Number of pages6
JournalNeuromuscular Disorders
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Autonomic nervous system
  • Cardiovascular reflex tests
  • Heart disturbances
  • Heart rate variability
  • Myotonic dystrophy type 1
  • Power spectral analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Neurology

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