Cardiovascular autonomic control in myotonic dystrophy type 1: A correlative study with clinical and genetic data

Rita Di Leo; Carmelo Rodolico; Cesare De Gregorio; Antonino Recupero; Sebastiano Coglitore; Grazia Annesi; Antonio Toscano; Corrado Messina; Giuseppe Vita

doi:10.1016/j.nmd.2003.11.002

Cardiovascular autonomic control in myotonic dystrophy type 1: A correlative study with clinical and genetic data

Rita Di Leo, Carmelo Rodolico, Cesare De Gregorio, Antonino Recupero, Sebastiano Coglitore, Grazia Annesi, Antonio Toscano, Corrado Messina, Giuseppe Vita

IRCCS Centro Neurolesi "Bonino Pulejo"

Research output: Contribution to journal › Article › peer-review

Abstract

The autonomic nervous system has been evaluated in myotonic dystrophy with contradictory results and its relationship with heart disturbances remains unclear. Twenty-three patients with myotonic dystrophy type 1 were investigated by a battery of six cardiovascular autonomic tests and power spectral analysis of heart rate variability. Although 15 patients (65%) revealed abnormal or borderline results in some tests, only one patient had a definite autonomic damage, as indicated by two or more abnormal tests. As a group, myotonic dystrophy type 1 patients showed a significant reduction of heart rate variability during deep breathing (P

Original language	English
Pages (from-to)	136-141
Number of pages	6
Journal	Neuromuscular Disorders
Volume	14
Issue number	2
DOIs	https://doi.org/10.1016/j.nmd.2003.11.002
Publication status	Published - Feb 2004

Keywords

Autonomic nervous system
Cardiovascular reflex tests
Heart disturbances
Heart rate variability
Myotonic dystrophy type 1
Power spectral analysis

ASJC Scopus subject areas

Clinical Neurology
Pediatrics, Perinatology, and Child Health
Developmental Neuroscience
Neurology

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Cardiovascular autonomic control in myotonic dystrophy type 1 : A correlative study with clinical and genetic data. / Di Leo, Rita; Rodolico, Carmelo; De Gregorio, Cesare; Recupero, Antonino; Coglitore, Sebastiano; Annesi, Grazia; Toscano, Antonio; Messina, Corrado; Vita, Giuseppe.

In: Neuromuscular Disorders, Vol. 14, No. 2, 02.2004, p. 136-141.

Research output: Contribution to journal › Article › peer-review

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