Abstract
We studied causal relations among heart period (HP), systolic arterial pressure (SAP) and respiration (R) according to the definition of Granger causality in the time domain. Autonomic pharmacological challenges were used to alter the complexity of cardiovascular control. Atropine (AT), propranolol and clonidine (CL) were administered to block muscarinic receptors, β-adrenergic receptors and centrally sympathetic outflow, respectively.We found that: (i) at baseline, HP and SAP interacted in a closed loop with a dominant causal direction from HP to SAP; (ii) pharmacological blockades did not alter the bidirectional closedloop interactions between HP and SAP, but AT reduced the dominance of the causal direction from HP to SAP; (iii) at baseline, bidirectional interactions between HP and R were frequently found; (iv) the closed-loop relation between HP and R was unmodified by the administration of drugs; (v) at baseline, unidirectional interactions from R to SAP were often found; and (vi) while AT induced frequently an uncoupling between R and SAP, CL favoured bidirectional interactions. These results prove that time domain measures of Granger causality can contribute to the description of cardiovascular control by suggesting the temporal direction of the interactions and by separating different causality schemes (e.g. closed loop versus unidirectional relations).
| Original language | English |
|---|---|
| Article number | 20120161 |
| Journal | Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences |
| Volume | 371 |
| Issue number | 1997 |
| DOIs | |
| Publication status | Published - Aug 28 2013 |
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Keywords
- Arterial pressure variability
- Autonomic nervous system
- Baroreflex
- Cardiovascular control
- Granger causality
- Heart rate variability
ASJC Scopus subject areas
- Mathematics(all)
- Physics and Astronomy(all)
- Engineering(all)
Cite this
Cardiovascular control and time domain granger causality : Insights from selective autonomic blockade. / Porta, Alberto; Castiglioni, Paolo; Di Rienzo, Marco; Bassani, Tito; Bari, Vlasta; Faes, Luca; Nollo, Giandomenico; Cividjan, Andrei; Quintin, Luc.
In: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 371, No. 1997, 20120161, 28.08.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular control and time domain granger causality
T2 - Insights from selective autonomic blockade
AU - Porta, Alberto
AU - Castiglioni, Paolo
AU - Di Rienzo, Marco
AU - Bassani, Tito
AU - Bari, Vlasta
AU - Faes, Luca
AU - Nollo, Giandomenico
AU - Cividjan, Andrei
AU - Quintin, Luc
PY - 2013/8/28
Y1 - 2013/8/28
N2 - We studied causal relations among heart period (HP), systolic arterial pressure (SAP) and respiration (R) according to the definition of Granger causality in the time domain. Autonomic pharmacological challenges were used to alter the complexity of cardiovascular control. Atropine (AT), propranolol and clonidine (CL) were administered to block muscarinic receptors, β-adrenergic receptors and centrally sympathetic outflow, respectively.We found that: (i) at baseline, HP and SAP interacted in a closed loop with a dominant causal direction from HP to SAP; (ii) pharmacological blockades did not alter the bidirectional closedloop interactions between HP and SAP, but AT reduced the dominance of the causal direction from HP to SAP; (iii) at baseline, bidirectional interactions between HP and R were frequently found; (iv) the closed-loop relation between HP and R was unmodified by the administration of drugs; (v) at baseline, unidirectional interactions from R to SAP were often found; and (vi) while AT induced frequently an uncoupling between R and SAP, CL favoured bidirectional interactions. These results prove that time domain measures of Granger causality can contribute to the description of cardiovascular control by suggesting the temporal direction of the interactions and by separating different causality schemes (e.g. closed loop versus unidirectional relations).
AB - We studied causal relations among heart period (HP), systolic arterial pressure (SAP) and respiration (R) according to the definition of Granger causality in the time domain. Autonomic pharmacological challenges were used to alter the complexity of cardiovascular control. Atropine (AT), propranolol and clonidine (CL) were administered to block muscarinic receptors, β-adrenergic receptors and centrally sympathetic outflow, respectively.We found that: (i) at baseline, HP and SAP interacted in a closed loop with a dominant causal direction from HP to SAP; (ii) pharmacological blockades did not alter the bidirectional closedloop interactions between HP and SAP, but AT reduced the dominance of the causal direction from HP to SAP; (iii) at baseline, bidirectional interactions between HP and R were frequently found; (iv) the closed-loop relation between HP and R was unmodified by the administration of drugs; (v) at baseline, unidirectional interactions from R to SAP were often found; and (vi) while AT induced frequently an uncoupling between R and SAP, CL favoured bidirectional interactions. These results prove that time domain measures of Granger causality can contribute to the description of cardiovascular control by suggesting the temporal direction of the interactions and by separating different causality schemes (e.g. closed loop versus unidirectional relations).
KW - Arterial pressure variability
KW - Autonomic nervous system
KW - Baroreflex
KW - Cardiovascular control
KW - Granger causality
KW - Heart rate variability
UR - http://www.scopus.com/inward/record.url?scp=84880516162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880516162&partnerID=8YFLogxK
U2 - 10.1098/rsta.2012.0161
DO - 10.1098/rsta.2012.0161
M3 - Article
C2 - 23858489
AN - SCOPUS:84880516162
VL - 371
JO - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
JF - Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
SN - 0962-8428
IS - 1997
M1 - 20120161
ER -