Cardiovascular control indexes in amyotrophic lateral sclerosis patients and their relation with clinical markers

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We studied the autonomic response to an orthostatic challenge (i.e. head-up tilt) in 52 amyotrophic lateral sclerosis (ALS) patients and 16 healthy subjects by means of power spectral analysis of heart period (HP) and systolic arterial pressure (SAP) variability. In addition, we verified the correlation of spectral indexes with clinical features of the ALS patients. Results showed that cardiovascular control of the ALS patients was impaired and this impairment was more evident from SAP series. While the revised Functional Rating Scale score, its bulbar subscore, and disease duration were uncorrelated with spectral indexes, the rate of the disease progression was positively correlated with the absolute low frequency power of SAP variability at rest and negatively correlated with the normalized high frequency power of HP variability during head-up tilt. We conclude that: i) spectral analysis of HP and SAP variability provides indexes helpful to quantify the impairment of the cardiovascular neural control in ALS patients; ii) patients with a faster disease progression are characterized by a higher vascular sympathetic drive and/or a depressed vagal cardiac regulation.

Original languageEnglish
Title of host publicationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages2055-2058
Number of pages4
Volume2015-November
ISBN (Print)9781424492718
DOIs
Publication statusPublished - Nov 4 2015
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015 - Milan, Italy
Duration: Aug 25 2015Aug 29 2015

Other

Other37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2015
CountryItaly
CityMilan
Period8/25/158/29/15

    Fingerprint

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

De Maria, B., Bari, V., Marchi, A., Barbic, F., Furlan, R., Mora, G., Vecchia, L. D., & Porta, A. (2015). Cardiovascular control indexes in amyotrophic lateral sclerosis patients and their relation with clinical markers. In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (Vol. 2015-November, pp. 2055-2058). [7318791] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2015.7318791