Abstract
Original language | English |
---|---|
Pages (from-to) | 932-943 |
Number of pages | 12 |
Journal | J. Card. Fail. |
Volume | 26 |
Issue number | 11 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- cardiopulmonary exercise test
- Heart failure
- MECKI score
- prognosis
Fingerprint
Dive into the research topics of 'Cardiovascular Death Risk in Recovered Mid-Range Ejection Fraction Heart Failure: Insights From Cardiopulmonary Exercise Test: Journal of Cardiac Failure'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Cardiovascular Death Risk in Recovered Mid-Range Ejection Fraction Heart Failure: Insights From Cardiopulmonary Exercise Test : Journal of Cardiac Failure. / MAGRÌ, D.; PIEPOLI, M.; CORRÀ, U.G.O. et al.
In: J. Card. Fail., Vol. 26, No. 11, 2020, p. 932-943.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Cardiovascular Death Risk in Recovered Mid-Range Ejection Fraction Heart Failure: Insights From Cardiopulmonary Exercise Test
T2 - Journal of Cardiac Failure
AU - MAGRÌ, D.
AU - PIEPOLI, M.
AU - CORRÀ, U.G.O.
AU - GALLO, G.
AU - MARUOTTI, A.
AU - VIGNATI, C.
AU - SALVIONI, E.
AU - MAPELLI, M.
AU - PAOLILLO, S.
AU - PERRONE FILARDI, P.
AU - GIROLA, D.
AU - METRA, M.
AU - SCARDOVI, A.B.
AU - LAGIOIA, R.
AU - LIMONGELLI, G.
AU - SENNI, M.
AU - SCRUTINIO, D.
AU - EMDIN, M.
AU - PASSINO, C.
AU - LOMBARDI, C.
AU - Cattadori, Gaia
AU - PARATI, G.
AU - CICOIRA, M.
AU - CORREALE, M.
AU - FRIGERIO, M.
AU - CLEMENZA, F.
AU - BUSSOTTI, M.
AU - GUAZZI, M.
AU - BADAGLIACCA, R.
AU - SCIOMER, S.
AU - DI LENARDA, A.
AU - MAGGIONI, A.L.D.O.
AU - SINAGRA, G.
AU - VOLPE, M.
AU - AGOSTONI, P.
AU - appendix), MECKI score Research Group (see
N1 - Cited By :2 Export Date: 5 March 2021 CODEN: JCFAF Correspondence Address: AGOSTONI, P.; Centro Cardiologico Monzino, IRCCS, Via Parea 4, 20138, Italy; email: piergiuseppe.agostoni@unimi.it References: Ponikowski, P., Voors, A.A., Anker, S.D., Bueno, H., Cleland, J.G., Coats, A.J., 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J2016;37:2129–200; Nadruz, W., West, E., Santos, M., Skali, H., Groarke, J.D., Forman, D.E., Heart failure and midrange ejection fraction implications of recovered ejection fraction for exercise tolerance and outcomes (2016) Circ Heart Fail, 9; O'Neill, J.O., Young, J.B., Pothier, C.E., Lauer, M.S., Peak oxygen consumption as a predictor of death in patients with heart failure receiving beta-blockers (2005) Circulation, 111, pp. 2313-2318; Gitt, A.K., Wasserman, K., Kilkowski, C., Kleemann, T., Kilkowski, A., Bangert, M., Exercise anaerobic threshold and ventilatory efficiency identify heart failure patients for high risk of early death (2002) Circulation, 106, pp. 3079-3084; Agostoni, P., Corrà, U., Cattadori, G., Veglia, F., La Gioia, R., Scardovi, A.B., on behalf of the MECKI Score Research Group. Metabolic exercise test data combined with cardiac and kidney indexes, the MECKI score: a multiparametric approach to heart failure prognosis (2013) Int J Cardiol, 167, pp. 2710-2718; Aaronson, K.D., Schwartz, J.S., Chen, T.M., Wong, K.L., Goin, J.E., Mancini, D.M., Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation (1997) Circulation, 95, pp. 2660-2667; Corrà, U., Agostoni, P., Giordano, A., Cattadori, G., Battaia, E., La Gioia, R., The metabolic exercise test data combined with Cardiac And Kidney Indexes (MECKI) score and prognosis in heart failure. A validation study (2016) Int J Cardiol, 203, pp. 1067-1072; Freitas, P., Aguiar, C., Ferreira, A., Tralhão, A., Ventosa, A., Mendes, M., Comparative analysis of four scores to stratify patients with heart failure and reduced ejection fraction (2017) Am J Cardiol, 120, pp. 443-449; Kouwert, I.J., Bakker, E.A., Cramer, M.J., Snoek, J.A., Eijsvogels, T.M., Comparison of MAGGIC and MECKI risk scores to predict mortality after cardiac rehabilitation among Dutch heart failure patients (2019) Eur J Prev Cardiol, , 2047487319865730; Agostoni, P., Paolillo, S., Mapelli, M., Gentile, P., Salvioni, E., Veglia, F., Multiparametric prognostic scores in chronic heart failure with reduced ejection fraction: a long-term comparison (2018) Eur J Heart Fail, 20, pp. 700-710; Sato, T., Yoshihisa, A., Kanno, Y., Suzuki, S., Yamaki, T., Sugimoto, K., Cardiopulmonary exercise testing as prognostic indicators: comparisons among heart failure patients with reduced, mid-range and preserved ejection fraction (2017) Eur J Prev Cardiol, 24, pp. 1979-1987; Nadruz, W., West, E., Sengelov, M., Santos, M., Groarke, J.D., Forman, D.E., Prognostic value of cardiopulmonary exercise testing in heart failure with reduced, midrange, and preserved ejection fraction (2017) J Am Heart Assoc, 6; Agostoni, P., Bianchi, M., Moraschi, A., Palermo, P., Cattadori, G., La Gioia, R., Work-rate affects cardiopulmonary exercise test results in heart failure (2005) Eur J Heart Fail, 7, pp. 498-504; Magrì, D., Corrà, U., Di Lenarda, A., Cattadori, G., Maruotti, A., Iorio, A., Cardiovascular mortality and chronotropic incompetence in systolic heart failure: the importance of a reappraisal of current cut-off criteria (2014) Eur J Heart Fail, 16, pp. 201-209; Wasserman, K., Hansen, J.E., Sue, D.Y., Stringer, W., Whipp, B.J., Normal values (2005) Principles of exercise testing and interpretation, pp. 160-182. , editor R Weinberg 4th ed. Lippincott Williams & Wilkins Philadelphia; Beaver, W.L., Wasserman, K., Whipp, B.J., A new method for detecting anaerobic threshold by gas exchange (1986) J Appl Physiol, 60, pp. 2020-2027; Guazzi, M., Myers, J., Arena, R., Cardiopulmonary exercise testing in the clinical and prognostic assessment of diastolic heart failure (2005) J Am Coll Cardiol, 46, pp. 1883-1890; Guazzi, M., Adams, V., Conraads, V., Halle, M., Mezzani, A., Vanhees, L., EACPR/AHA Scientific Statement. Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations (2012) Circulation, 126, pp. 2261-2274; Guazzi, M., Bandera, F., Ozemek, C., Systrom, D., Arena, R., Cardiopulmonary exercise testing what is its value? (2017) J Am Coll Cardiol, 70, pp. 1618-1636; Corrà, U., Agostoni, P.G., Anker, S.D., Coats, A.J.S., Crespo Leiro, M.G., de Boer, R.A., Role of cardiopulmonary exercise testing in clinical stratification in heart failure. A position paper from the Committee on Exercise Physiology and Training of the Heart Failure Association of the European Society of Cardiology (2018) Eur J Heart Fail, 20, pp. 3-15; Lam, C.S., Solomon, S.D., The middle child in heart failure: heart failure with mid-range ejection fraction (40-50%) (2014) Eur J Heart Fail, 16, pp. 1049-1055; Lam, C.S., Solomon, S.D., Fussing over the middle child: heart failure with mid-range ejection fraction (2017) Circulation, 135 (14), pp. 1279-1280; Rickenbacker, P., Kaufmann, B.A., Maeder, M.T., Bernheim, A., Goetschalckx, K., Pfister, O., Heart failure with mid-range ejection fraction: a distinct clinical entity? Insights from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME-CHF) (2017) Eur J Heart Fail, 19, pp. 1586-1596; Triposkiadis, F., Butler, J., Abboud, F.M., Armstrong, P.W., Adamopoulos, S., Atherton, J.J., The continuous heart failure spectrum: moving beyond an ejection fraction classification (2019) Eur Heart J, 40, pp. 2155-2163; Sweitzer, N.K., Lopatin, M., Yancy, C.W., Mills, R.M., Stevenson, L.W., Comparison of clinical features and outcomes of patients hospitalized with heart failure and normal ejection fraction (>or =55%) versus those with mildly reduced (40% to 55%) and moderately to severely reduced (<40%) fractions (2008) Am J Cardiol, 101, pp. 1151-1156; Tsuji, K., Sakata, Y., Nochioka, K., Miura, M., Yamauchi, T., Onose, T., Characterization of heart failure patients with mid-range left ventricular ejection fraction-a report from the CHART-2 Study (2017) Eur J Heart Fail, 19, pp. 1258-1269; Koh, A.S., Tay, W.T., Teng, T.H.K., Vedin, O., Benson, L., Dahlstrom, U., A comprehensive population-based characterization of heart failure with mid-range ejection fraction (2017) Eur J Heart Fail, 19, pp. 1624-1634; Rastogi, A., Novak, E., Platts, A.E., Mann, D.L., Epidemiology, pathophysiology and clinical outcomes for heart failure patients with a mid-range ejection fraction (2017) Eur J Heart Fail, 19, pp. 1597-1605; Basuray, A., French, B., Ky, B., Vorovich, E., Olt, C., Sweitzer, N.K., Heart failure with recovered ejection fraction: clinical description, biomarkers, and outcomes (2014) Circulation, 129, pp. 2380-2387; Punnoose, L.R., Givertz, M.M., Lewis, E.F., Pratibhu, P., Stevenson, L.W., Desai, A.S., Heart failure with recovered ejection fraction: a distinct clinical entity (2011) J Card Fail, 17, pp. 527-532; Hsu, J.J., Ziaeian, B., Fonarow, G.C., Heart failure with mid-range (borderline) ejection fraction: clinical implications and future directions (2017) JACC Heart Fail, 5, pp. 763-771; Choi, K.H., Choi, J.O., Jeon, E.S., Lee, G.Y., Choi, D.J., Lee, H.Y., Guideline-directed medical therapy for patients with heart failure with midrange ejection fraction: a patient-pooled analysis from the Kor HF and Kor AHF Registries (2018) J Am Heart Assoc, 7; Ibrahim, N.E., Song, Y., Cannon, C.P., Doros, G., Russo, P., Ponirakis, A., Heart failure with mid-range ejection fraction: characterization of patients from the PINNACLE Registry (2019) ESC Heart Fail, 6, pp. 784-792; Nadar, S.K., Tariq, O., What is heart failure with mid-range ejection fraction? A new subgroup of patients with heart failure (2018) Card Fail Rev, 4, p. 6—8; Park, C.S., Park, J.J., Mebazaa, A., Oh, I.Y., Park, H.A., Cho, H.J., Characteristic, Outcomes, and treatment of heart failure with improved ejection fraction (2019) J Am Heart Assoc, 8; Salvioni, E., Corrà, U., Piepoli, M., Rovai, S., Correale, M., Paolillo, S., Gender and age normalization and ventilation efficiency during exercise in heart failure with reduced ejection fraction (2020) ESC Heart Fail, 7, pp. 371-380; Magrì, D., Peak oxygen uptake in heart failure: look behind the number! (2018) Eur J Prev Cardiol, 25, pp. 1934-1936; Klaassen, S.H.C., Liu, L.C.Y., Hummel, Y.M., Damman, K., van der Meer, P., Voors, A.A., Clinical and hemodynamic correlates and prognostic value of VE/VCO2 slope in patients with heart failure with preserved ejection fraction and pulmonary hypertension (2017) J Card Fail, 23, pp. 777-782
PY - 2020
Y1 - 2020
N2 - Background: Heart failure with midrange ejection fraction (HFmrEF) represents a heterogeneous category where phenotype, as well as prognostic assessment, remains debated. The present study explores a specific HFmrEF subset, namely those who recovered from a reduced EF (rec-HFmrEF) and, particularly, it focuses on the possible additive prognostic role of cardiopulmonary exercise testing. Methods and Results: We analyzed data from 4535 patients with HFrEF and 1176 patients with rec-HFmrEF from the Metabolic Exercise combined with Cardiac and Kidney Indexes database. The end point was cardiovascular death at 5 years. The median follow-up was 1343 days (25th–75th range 627–2403 days). Cardiovascular death occurred in 552 HFrEF and 61 rec-HFmrEF patients. The multivariate analysis confirmed an independent role of the MECKI score's variables in HFrEF (C-index = 0.744) whereas, in the rec-HFmrEF group, only age and peak oxygen uptake (pVO2) remained associated to the end point (C-index = 0.745). A peak oxygen uptake of ≤55% of predicted and a ventilatory efficiency of ≥31 resulted as the most accurate cut-off values in the outcome prediction. Conclusions: Present data support the cardiopulmonary exercise test and, particularly, the peak oxygen uptake, as a useful tool in the rec-HFmrEF prognostic assessment. A peak VO2 of ≤55% predicted and ventilatory efficiency of ≥31 might help to identify a high-risk rec-HFmrEF subgroup. © 2020 Elsevier Inc.
AB - Background: Heart failure with midrange ejection fraction (HFmrEF) represents a heterogeneous category where phenotype, as well as prognostic assessment, remains debated. The present study explores a specific HFmrEF subset, namely those who recovered from a reduced EF (rec-HFmrEF) and, particularly, it focuses on the possible additive prognostic role of cardiopulmonary exercise testing. Methods and Results: We analyzed data from 4535 patients with HFrEF and 1176 patients with rec-HFmrEF from the Metabolic Exercise combined with Cardiac and Kidney Indexes database. The end point was cardiovascular death at 5 years. The median follow-up was 1343 days (25th–75th range 627–2403 days). Cardiovascular death occurred in 552 HFrEF and 61 rec-HFmrEF patients. The multivariate analysis confirmed an independent role of the MECKI score's variables in HFrEF (C-index = 0.744) whereas, in the rec-HFmrEF group, only age and peak oxygen uptake (pVO2) remained associated to the end point (C-index = 0.745). A peak oxygen uptake of ≤55% of predicted and a ventilatory efficiency of ≥31 resulted as the most accurate cut-off values in the outcome prediction. Conclusions: Present data support the cardiopulmonary exercise test and, particularly, the peak oxygen uptake, as a useful tool in the rec-HFmrEF prognostic assessment. A peak VO2 of ≤55% predicted and ventilatory efficiency of ≥31 might help to identify a high-risk rec-HFmrEF subgroup. © 2020 Elsevier Inc.
KW - cardiopulmonary exercise test
KW - Heart failure
KW - MECKI score
KW - prognosis
U2 - 10.1016/j.cardfail.2020.04.021
DO - 10.1016/j.cardfail.2020.04.021
M3 - Article
VL - 26
SP - 932
EP - 943
JO - J. Card. Fail.
JF - J. Card. Fail.
SN - 1071-9164
IS - 11
ER -