Cardiovascular disease

Amelia Casamassimi, Monica Rienzo, Claudio Napoli

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Despite the use of systems biology is still at the beginning in the study of complex diseases, the '-omics'strategies are already contributing to novel insights into atherosclerosis and CVDs. The promise of this approach includes disease risk prediction and prevention as well as the possibility of personalized therapy. In this concern, research interest has been recently focused on evaluating the role of endothelial progenitor cells in tissue vascularization and regeneration. This circulating cell population has also been proposed as potential clinical marker for several diseases including cardiovascular ones, where they have begun to be used as a new therapeutic option [23]. Recent in vivo proteomic data suggest a potential effect of acute coronary syndrome in the protein profiles of these cells [24]. These findings suggest that integrated 'omics technologies, including metabolomics, may help to better characterize these cells and understand their biology as well as their pathophysiological role in CVD and tissue regeneration.

Original languageEnglish
Title of host publicationGlobal Metabolic Profiling: Clinical Applications
PublisherFuture Medicine Ltd.
Pages96-108
Number of pages13
ISBN (Print)9781909453616, 9781909453623
DOIs
Publication statusPublished - Jan 1 2014

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ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Casamassimi, A., Rienzo, M., & Napoli, C. (2014). Cardiovascular disease. In Global Metabolic Profiling: Clinical Applications (pp. 96-108). Future Medicine Ltd.. https://doi.org/10.4155/EBO.13.452