Abstract
Anorexia nervosa (AN) is an eating disorder in which a distorted self-perception of body image and an excessive fear of gaining weight result in extreme restrictions in eating habits. AN may be divided into two types: a “binge-eating/purging type” during which the individual regularly engages in overeating and then purging behavior, and a “restricting type”, in which she does not. AN is a serious medical problem in young people in Western societies. It is widely reported that patients with AN exhibit an enhanced mortality rate as compared with age-matched healthy subjects, which has been mainly ascribed to cardiac complications. At least one-third of all deaths in patients with anorexia nervosa are estimated to be due to cardiac causes, mainly sudden death. Cardiovascular complications of AN can be present in up to 80 % of cases, and among them alterations in cardiac electrical activity, structure and hemodynamics have been reported as causes of morbidity and mortality. The objective of this brief review is to summarize current knowledge on the main cardiovascular complications of AN, their underlying mechanisms and the possible therapeutic approaches.
| Original language | English |
|---|---|
| Pages (from-to) | 717-721 |
| Number of pages | 5 |
| Journal | Internal and Emergency Medicine |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Oct 2 2014 |
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Keywords
- Anorexia nervosa
- Cardiac complication
- Clinical management
- Mechanisms
ASJC Scopus subject areas
- Emergency Medicine
- Internal Medicine
Cite this
Cardiovascular disorders in anorexia nervosa and potential therapeutic targets. / Di Cola, Giovanni; Jacoangeli, Francesca; Jacoangeli, Fabrizio; Lombardo, Mauro; Iellamo, Ferdinando.
In: Internal and Emergency Medicine, Vol. 9, No. 7, 02.10.2014, p. 717-721.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular disorders in anorexia nervosa and potential therapeutic targets
AU - Di Cola, Giovanni
AU - Jacoangeli, Francesca
AU - Jacoangeli, Fabrizio
AU - Lombardo, Mauro
AU - Iellamo, Ferdinando
PY - 2014/10/2
Y1 - 2014/10/2
N2 - Anorexia nervosa (AN) is an eating disorder in which a distorted self-perception of body image and an excessive fear of gaining weight result in extreme restrictions in eating habits. AN may be divided into two types: a “binge-eating/purging type” during which the individual regularly engages in overeating and then purging behavior, and a “restricting type”, in which she does not. AN is a serious medical problem in young people in Western societies. It is widely reported that patients with AN exhibit an enhanced mortality rate as compared with age-matched healthy subjects, which has been mainly ascribed to cardiac complications. At least one-third of all deaths in patients with anorexia nervosa are estimated to be due to cardiac causes, mainly sudden death. Cardiovascular complications of AN can be present in up to 80 % of cases, and among them alterations in cardiac electrical activity, structure and hemodynamics have been reported as causes of morbidity and mortality. The objective of this brief review is to summarize current knowledge on the main cardiovascular complications of AN, their underlying mechanisms and the possible therapeutic approaches.
AB - Anorexia nervosa (AN) is an eating disorder in which a distorted self-perception of body image and an excessive fear of gaining weight result in extreme restrictions in eating habits. AN may be divided into two types: a “binge-eating/purging type” during which the individual regularly engages in overeating and then purging behavior, and a “restricting type”, in which she does not. AN is a serious medical problem in young people in Western societies. It is widely reported that patients with AN exhibit an enhanced mortality rate as compared with age-matched healthy subjects, which has been mainly ascribed to cardiac complications. At least one-third of all deaths in patients with anorexia nervosa are estimated to be due to cardiac causes, mainly sudden death. Cardiovascular complications of AN can be present in up to 80 % of cases, and among them alterations in cardiac electrical activity, structure and hemodynamics have been reported as causes of morbidity and mortality. The objective of this brief review is to summarize current knowledge on the main cardiovascular complications of AN, their underlying mechanisms and the possible therapeutic approaches.
KW - Anorexia nervosa
KW - Cardiac complication
KW - Clinical management
KW - Mechanisms
UR - http://www.scopus.com/inward/record.url?scp=84918768288&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84918768288&partnerID=8YFLogxK
U2 - 10.1007/s11739-014-1107-2
DO - 10.1007/s11739-014-1107-2
M3 - Article
C2 - 25056404
AN - SCOPUS:84918768288
VL - 9
SP - 717
EP - 721
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
IS - 7
ER -