Cardiovascular effects induced by lateral hypothalamic stimulation in anesthetized cats

P. L. De Riu, V. A. Sironi, A. Franzini

Research output: Contribution to journalArticlepeer-review


Cardiovascular phenomena induced by electrical stimulation of the lateral hypothalamus were investigated with particular attention to a possible parasympathetic effect. In pentobarbital anesthetized cats a microelectrode was stereotactically inserted in the lateral hypothalamus. The arterial blood pressure was monitored from the femoral artery and an ECG was recorded by needle electrodes (Lead II). Each target was stimulated at increasing voltage intensities. Responsive points eliciting bradycardia were marked by an electrolytic lesion and histologically controlled. Sixty stimulated points produced tachycardia with increased width of QRS complex, T waves and isolated ectopic beats. Of six points (in six different animals) which led to bradycardia, two showed the severe bioelectrical changes of myocardial infarct, at increasing intensity of stimulus. Arterial hypertension followed the stimulation of all responsive sites. Histological study showed that bradycardic eliciting points lie among those producing tachycardia in a discrete area of the lateral hypothalamus.

Original languageEnglish
Pages (from-to)32-33
Number of pages2
JournalIRCS Medical Science
Issue number1
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


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