Cardiovascular effects of brain kinin receptor blockade in spontaneously hypertensive rats

Paolo Madeddu, Nicola Glorioso, Maria Vittoria Varoni, Maria Piera Demontis, Maria Caterina Fattaccio, Vittorio Anania

Research output: Contribution to journalArticlepeer-review


We studied the role of brain kinins in the regulation of cardiovascular function. Intracerebroventricular injection of 380 pmol bradykinin increased mean blood pressure by 20±2 mm Hg (p2 receptor antagonist D-Arg,[Hyp3,Thi5,D-Tic7, Oic8-bradykinin (Hoe 140). On a molar basis, Hoe 140 was two orders of magnitude more potent than antagonists of the first generation. Baroreceptor sensitivity, estimated as the heart rate response to blood pressure changes induced by intravenous injection of phenylephrine or sodium nitroprusside, was not altered by Hoe 140 in WKY rats. In spontaneously hypertensive rats (SHR), baroreceptor reflex sensitivity to increments in mean blood pressure was reduced by Hoe 140 mean slope value: −0.47±0.07 versus −0.92±0.13 beats per minute per millimeter of mercury in controls, PP2 receptors to affect normal blood pressure of WKY rats and to blunt the progression of hypertension in SHR does not favor the hypothesis that brain kinins are involved in the regulation of blood pressure. On the other hand, the present study suggests modulation of barorereceptor reflex sensitivity by brain kinins in genetic hypertension.

Original languageEnglish
Pages (from-to)I-189-I-192
Issue number1
Publication statusPublished - 1994


  • Hypertension, essential
  • Kallikrein
  • Kinins
  • Pressoreceptors

ASJC Scopus subject areas

  • Internal Medicine


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