Cardiovascular effects of lisuride continuous intravenous infusion in fluctuating Parkinson's disease

A. Capria, A. Attanasio, M. Quatrana, D. Cannata, M. Fioravanti, F. Stocchi, S. Ruggieri

Research output: Contribution to journalArticlepeer-review

Abstract

The cardiovascular effects of a continuous intravenous infusion of lisuride plus oral domperidone were studied in 16 fluctuating parkinsonian patients as compared to their usual oral therapy with levodopa plus carbidopa. The study was performed using a 24-h ambulatory recording and an automatic noninvasive device for blood pressure monitoring. During lisuride infusion, a significant increase of systolic blood pressure was observed; however, in three patients, a decrease of systolic-diastolic blood pressure occurred; furthermore, a mild increase of atrial arrhythmias and, in two patients, a short run of atrial fibrillation were noted. Asymptomatic orthostatic hypotension, observed in seven patients during levodopa therapy, disappeared during lisuride infusion. Paradoxical hypertensive effects and disappearance of orthostatic hypotension observed in our patients seem related to concurrent administration of domperidone.

Original languageEnglish
Pages (from-to)331-338
Number of pages8
JournalClinical Neuropharmacology
Volume12
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Clinical Neurology
  • Pharmacology (medical)
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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