Cardiovascular events in patients with mild autonomous cortisol secretion: analysis with artificial neural networks

Research output: Contribution to journalArticle

Abstract

BACKGROUND: The independent role of mild autonomous cortisol secretion (ACS) in influencing the cardiovascular event (CVE) occurrence is a topic of interest. We investigated the role of mild ACS in the CVE occurrence in patients with adrenal incidentaloma (AI) by standard statistics and artificial neural networks (ANNs).METHODS: We analyzed a retrospective record of 518 AI patients. Data regarding cortisol levels after 1 mg dexamethasone suppression (1 mg DST) and the presence of obesity (OB), hypertension (AH), type-2 diabetes (T2DM), dyslipidemia (DL), familial CVE history, smoking habit and CVE were collected.RESULTS: The receiver-operating characteristic curve analysis suggested that 1 mg DST, at a cut-off of 1.8 µg/dL, had the best accuracy for detecting patients with increased CVE risk. In patients with 1 mg-DST ≥1.8 µg/dL (DST+,n = 223), age and prevalence of AH, T2DM, DL and CVE (66 years, 74.5, 25.9, 41.4 and 26.8% respectively) were higher than that of patients with 1 mg-DST ≤1.8 µg/dL (61.9 years, 60.7, 18.5, 32.9 and 10%, respectively,P 
Original languageEnglish
Pages (from-to)73-83
Number of pages11
JournalEuropean Journal of Endocrinology
Volume177
Issue number1
DOIs
Publication statusPublished - Jul 2017

Keywords

  • Adrenal Gland Neoplasms
  • Adult
  • Age Factors
  • Aged
  • Cardiovascular Diseases
  • Dexamethasone
  • Diabetes Mellitus, Type 2
  • Dyslipidemias
  • Female
  • Humans
  • Hydrocortisone
  • Hypertension
  • Male
  • Middle Aged
  • Neural Networks (Computer)
  • Obesity
  • Prevalence
  • Retrospective Studies
  • Smoking
  • Journal Article
  • Multicenter Study
  • Observational Study

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