TY - JOUR
T1 - Cardiovascular injury in systemic autoimmune diseases
T2 - an update.
AU - Turiel, Maurizio
AU - Sarzi-Puttini, Piercarlo
AU - Atzeni, Fabiola
AU - De Gennaro Colonna, Vito
AU - Gianturco, Luigi
AU - Tomasoni, Livio
PY - 2011/10
Y1 - 2011/10
N2 - It is well known in literature that systemic autoimmune diseases (SADs) are associated with enhanced atherosclerosis and impaired endothelial function early after the onset of the disease. Cardiovascular (CV) disease represents one of the leading causes of morbidity and mortality in SADs. There is considerable evidence suggesting a pathogenetic role of chronic inflammation and immune dysregulation for enhanced atherosclerosis in SADs, as demonstrated in several recent studies. Moreover, chronic inflammation, accelerated atherosclerosis and functional abnormalities of the endothelium suggest a subclinical CV involvement beginning rapidly soon after the onset of the disease and progressing with disease duration.
AB - It is well known in literature that systemic autoimmune diseases (SADs) are associated with enhanced atherosclerosis and impaired endothelial function early after the onset of the disease. Cardiovascular (CV) disease represents one of the leading causes of morbidity and mortality in SADs. There is considerable evidence suggesting a pathogenetic role of chronic inflammation and immune dysregulation for enhanced atherosclerosis in SADs, as demonstrated in several recent studies. Moreover, chronic inflammation, accelerated atherosclerosis and functional abnormalities of the endothelium suggest a subclinical CV involvement beginning rapidly soon after the onset of the disease and progressing with disease duration.
UR - http://www.scopus.com/inward/record.url?scp=84857073374&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857073374&partnerID=8YFLogxK
M3 - Article
C2 - 22009619
AN - SCOPUS:84857073374
VL - 6 Suppl 1
SP - 99
EP - 102
JO - Internal and Emergency Medicine
JF - Internal and Emergency Medicine
SN - 1828-0447
ER -