Cardiovascular injury in systemic autoimmune diseases: an update.

Maurizio Turiel, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Vito De Gennaro Colonna, Luigi Gianturco, Livio Tomasoni

Research output: Contribution to journalArticlepeer-review

Abstract

It is well known in literature that systemic autoimmune diseases (SADs) are associated with enhanced atherosclerosis and impaired endothelial function early after the onset of the disease. Cardiovascular (CV) disease represents one of the leading causes of morbidity and mortality in SADs. There is considerable evidence suggesting a pathogenetic role of chronic inflammation and immune dysregulation for enhanced atherosclerosis in SADs, as demonstrated in several recent studies. Moreover, chronic inflammation, accelerated atherosclerosis and functional abnormalities of the endothelium suggest a subclinical CV involvement beginning rapidly soon after the onset of the disease and progressing with disease duration.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalInternal and Emergency Medicine
Volume6 Suppl 1
Publication statusPublished - Oct 2011

ASJC Scopus subject areas

  • Emergency Medicine
  • Internal Medicine

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