Cardiovascular involvement in patients affected by acromegaly: An appraisal

Susanna Mosca, Stefania Paolillo, Annamaria Colao, Eduardo Bossone, Antonio Cittadini, Francesco Lo Iudice, Antonio Parente, Sirio Conte, Giuseppe Rengo, Dario Leosco, Bruno Trimarco, Pasquale Perrone Filardi

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiovascular complications are frequent in acromegalic patients. Several studies reported increased prevalence of traditional cardiovascular risk factors and early development of endothelial dysfunction and of structural vascular alterations, with subsequent increased risk of coronary artery disease. Furthermore, chronic exposure to high levels of GH and IGF-I leads to the development of the so called "acromegalic cardiomyopathy", characterized by concentric biventricular hypertrophy, diastolic dysfunction and, additionally, by progressive impairment of systolic performance leading to overt heart failure. Cardiac valvulopathies and arrhythmias have also been documented and may concur to the deterioration of cardiac function. Together with strict control of cardiovascular risk factors, early control of GH and IGF-I excess, by surgical or pharmacological therapy, has been reported to ameliorate cardiac and metabolic abnormalities, leading to a significant reduction of left ventricular hypertrophy and to a consistent improvement of cardiac performance.

Original languageEnglish
Pages (from-to)1712-1718
Number of pages7
JournalInternational Journal of Cardiology
Volume167
Issue number5
DOIs
Publication statusPublished - Sep 1 2013

Keywords

  • Acromegalic cardiomyopathy
  • Acromegaly
  • GH/IGF-I excess
  • Premature atherosclerosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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