Coinvolgimento cardiovascolare nell'artrite psoriasica

Translated title of the contribution: Cardiovascular involvement in psoriatic arthritis

F. Atzeni, M. Turiel, L. Boccassini, S. Sitia, L. Tomasoni, M. Battellino, A. Marchesoni, V. de Gennaro Colonna, P. Sarzi-Puttini

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Psoriasis is a chronic, genetically determined and immunomediated inflammatory skin disease that affects 2-3% of the Caucasian population. A considerable proportion of these patients develop a form of inflammatory arthritis known as psoriatic arthritis (PsA), although the prevalence of this has not been well defined. Patients with PsA have a higher mortality rate than the general population and the risk of mortality is related to disease severity at the time of presentation. Endothelial dysfunction and early atherosclerosis have been found in patients with PsA without any cardiovascular disease (CVD) risk factors, and experts believe that CVD is one of the leading causes of death, as it is in patients with rheumatoid arthritis (RA). Various disease-related mechanisms may be involved in the development of premature vascular damage in both cases, including an increased synthesis of proinflammatory mediators (such as cytokines, chemokines and adhesion molecules), autoantibodies against endothelial cell components, perturbations in T-cell subsets, genetic polymorphisms, hyperhomocysteinemia, oxidative stress, abnormal vascular repair, and iatrogenic factors. In a recent study of 22 patients with PsA without any signs of CVD, we found that the plasma concentration of asymmetric dimethylarginine (ADMA) levels were significantly high and coronary flow reserve (CFR) was significantly reduced. Moreover, there was a significant correlation between CFR and plasma ADMA levels in the PsA group. The significant correlation between the reduced CRF and increased ADMA levels suggests that, like patients with early RA, PsA patients suffer from endothelial dysfunction and impaired coronary microcirculation. Active PsA is a risk factor for CVD, and so PsA patients should be screened for subclinical forms of the disease and its risk factors, and an early treatment approach should be adopted. Parole chiave: artrite psoriasica; coinvolgimento cardiovascolare; dimetil-arginina asimmetrica; fattori di rischio.

Original languageItalian
Pages (from-to)148-154
Number of pages7
JournalReumatismo
Volume63
Issue number3
Publication statusPublished - 2011

Fingerprint

Psoriatic Arthritis
Cardiovascular Diseases
Blood Vessels
Rheumatoid Arthritis
Hyperhomocysteinemia
Mortality
T-Lymphocyte Subsets
Genetic Polymorphisms
Cellular Structures
Microcirculation
Chemokines
Psoriasis
Skin Diseases
Autoantibodies
Population
Arthritis
Cause of Death
Atherosclerosis
Oxidative Stress
Endothelial Cells

ASJC Scopus subject areas

  • Rheumatology

Cite this

Atzeni, F., Turiel, M., Boccassini, L., Sitia, S., Tomasoni, L., Battellino, M., ... Sarzi-Puttini, P. (2011). Coinvolgimento cardiovascolare nell'artrite psoriasica. Reumatismo, 63(3), 148-154.

Coinvolgimento cardiovascolare nell'artrite psoriasica. / Atzeni, F.; Turiel, M.; Boccassini, L.; Sitia, S.; Tomasoni, L.; Battellino, M.; Marchesoni, A.; de Gennaro Colonna, V.; Sarzi-Puttini, P.

In: Reumatismo, Vol. 63, No. 3, 2011, p. 148-154.

Research output: Contribution to journalArticle

Atzeni, F, Turiel, M, Boccassini, L, Sitia, S, Tomasoni, L, Battellino, M, Marchesoni, A, de Gennaro Colonna, V & Sarzi-Puttini, P 2011, 'Coinvolgimento cardiovascolare nell'artrite psoriasica', Reumatismo, vol. 63, no. 3, pp. 148-154.
Atzeni F, Turiel M, Boccassini L, Sitia S, Tomasoni L, Battellino M et al. Coinvolgimento cardiovascolare nell'artrite psoriasica. Reumatismo. 2011;63(3):148-154.
Atzeni, F. ; Turiel, M. ; Boccassini, L. ; Sitia, S. ; Tomasoni, L. ; Battellino, M. ; Marchesoni, A. ; de Gennaro Colonna, V. ; Sarzi-Puttini, P. / Coinvolgimento cardiovascolare nell'artrite psoriasica. In: Reumatismo. 2011 ; Vol. 63, No. 3. pp. 148-154.
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