Cardiovascular involvement in systemic autoimmune diseases

Simona Sitia, Fabiola Atzeni, Piercarlo Sarzi-Puttini, Vitantonio Di Bello, Livio Tomasoni, Luigi Delfino, Francesco Antonini-Canterin, Giovanni Di Salvo, Vito De Gennaro Colonna, Salvatore La Carrubba, Scipione Carerj, Maurizio Turiel

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary antiphospholipid syndrome (APS), systemic sclerosis and systemic vasculitis, affect a large number of people in whom one of the leading causes of morbidity and mortality is cardiovascular disease. Cardiovascular disease is associated with the development of accelerated atherosclerosis. It seems to occur at a younger age than in the general population, is often asymptomatic and, in addition to traditional risk factors, also involves specific risk factors as chronic inflammation, the duration and activity of the autoimmune disease, and immunosuppressive therapy. The early phases of cardiovascular involvement in patients with autoimmune diseases may be clinically silent, with only a microcirculation disorder present. There are various means of detecting morphological cardiac damage: coronary angiography remains the gold standard for diagnosing coronary stenosis, but new, non invasive and more reliable methods have been introduced into clinical practice in order to detect subclinical microcirculation abnormalities.

Original languageEnglish
Pages (from-to)281-286
Number of pages6
JournalAutoimmunity Reviews
Volume8
Issue number4
DOIs
Publication statusPublished - Feb 2009

Fingerprint

Autoimmune Diseases
Microcirculation
Cardiovascular Diseases
Systemic Vasculitis
Antiphospholipid Syndrome
Systemic Scleroderma
Coronary Stenosis
Immunosuppressive Agents
Coronary Angiography
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Atherosclerosis
Inflammation
Morbidity
Mortality
Population
Therapeutics

Keywords

  • Coronary angiography
  • Microcirculation abnormalities
  • Non-invasive diagnostic tools
  • Systemic autoimmune diseases

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Sitia, S., Atzeni, F., Sarzi-Puttini, P., Di Bello, V., Tomasoni, L., Delfino, L., ... Turiel, M. (2009). Cardiovascular involvement in systemic autoimmune diseases. Autoimmunity Reviews, 8(4), 281-286. https://doi.org/10.1016/j.autrev.2008.08.004

Cardiovascular involvement in systemic autoimmune diseases. / Sitia, Simona; Atzeni, Fabiola; Sarzi-Puttini, Piercarlo; Di Bello, Vitantonio; Tomasoni, Livio; Delfino, Luigi; Antonini-Canterin, Francesco; Di Salvo, Giovanni; De Gennaro Colonna, Vito; La Carrubba, Salvatore; Carerj, Scipione; Turiel, Maurizio.

In: Autoimmunity Reviews, Vol. 8, No. 4, 02.2009, p. 281-286.

Research output: Contribution to journalArticle

Sitia, S, Atzeni, F, Sarzi-Puttini, P, Di Bello, V, Tomasoni, L, Delfino, L, Antonini-Canterin, F, Di Salvo, G, De Gennaro Colonna, V, La Carrubba, S, Carerj, S & Turiel, M 2009, 'Cardiovascular involvement in systemic autoimmune diseases', Autoimmunity Reviews, vol. 8, no. 4, pp. 281-286. https://doi.org/10.1016/j.autrev.2008.08.004
Sitia S, Atzeni F, Sarzi-Puttini P, Di Bello V, Tomasoni L, Delfino L et al. Cardiovascular involvement in systemic autoimmune diseases. Autoimmunity Reviews. 2009 Feb;8(4):281-286. https://doi.org/10.1016/j.autrev.2008.08.004
Sitia, Simona ; Atzeni, Fabiola ; Sarzi-Puttini, Piercarlo ; Di Bello, Vitantonio ; Tomasoni, Livio ; Delfino, Luigi ; Antonini-Canterin, Francesco ; Di Salvo, Giovanni ; De Gennaro Colonna, Vito ; La Carrubba, Salvatore ; Carerj, Scipione ; Turiel, Maurizio. / Cardiovascular involvement in systemic autoimmune diseases. In: Autoimmunity Reviews. 2009 ; Vol. 8, No. 4. pp. 281-286.
@article{ea0629169c4c4e8fb35a407c5e819958,
title = "Cardiovascular involvement in systemic autoimmune diseases",
abstract = "Autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary antiphospholipid syndrome (APS), systemic sclerosis and systemic vasculitis, affect a large number of people in whom one of the leading causes of morbidity and mortality is cardiovascular disease. Cardiovascular disease is associated with the development of accelerated atherosclerosis. It seems to occur at a younger age than in the general population, is often asymptomatic and, in addition to traditional risk factors, also involves specific risk factors as chronic inflammation, the duration and activity of the autoimmune disease, and immunosuppressive therapy. The early phases of cardiovascular involvement in patients with autoimmune diseases may be clinically silent, with only a microcirculation disorder present. There are various means of detecting morphological cardiac damage: coronary angiography remains the gold standard for diagnosing coronary stenosis, but new, non invasive and more reliable methods have been introduced into clinical practice in order to detect subclinical microcirculation abnormalities.",
keywords = "Coronary angiography, Microcirculation abnormalities, Non-invasive diagnostic tools, Systemic autoimmune diseases",
author = "Simona Sitia and Fabiola Atzeni and Piercarlo Sarzi-Puttini and {Di Bello}, Vitantonio and Livio Tomasoni and Luigi Delfino and Francesco Antonini-Canterin and {Di Salvo}, Giovanni and {De Gennaro Colonna}, Vito and {La Carrubba}, Salvatore and Scipione Carerj and Maurizio Turiel",
year = "2009",
month = "2",
doi = "10.1016/j.autrev.2008.08.004",
language = "English",
volume = "8",
pages = "281--286",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "4",

}

TY - JOUR

T1 - Cardiovascular involvement in systemic autoimmune diseases

AU - Sitia, Simona

AU - Atzeni, Fabiola

AU - Sarzi-Puttini, Piercarlo

AU - Di Bello, Vitantonio

AU - Tomasoni, Livio

AU - Delfino, Luigi

AU - Antonini-Canterin, Francesco

AU - Di Salvo, Giovanni

AU - De Gennaro Colonna, Vito

AU - La Carrubba, Salvatore

AU - Carerj, Scipione

AU - Turiel, Maurizio

PY - 2009/2

Y1 - 2009/2

N2 - Autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary antiphospholipid syndrome (APS), systemic sclerosis and systemic vasculitis, affect a large number of people in whom one of the leading causes of morbidity and mortality is cardiovascular disease. Cardiovascular disease is associated with the development of accelerated atherosclerosis. It seems to occur at a younger age than in the general population, is often asymptomatic and, in addition to traditional risk factors, also involves specific risk factors as chronic inflammation, the duration and activity of the autoimmune disease, and immunosuppressive therapy. The early phases of cardiovascular involvement in patients with autoimmune diseases may be clinically silent, with only a microcirculation disorder present. There are various means of detecting morphological cardiac damage: coronary angiography remains the gold standard for diagnosing coronary stenosis, but new, non invasive and more reliable methods have been introduced into clinical practice in order to detect subclinical microcirculation abnormalities.

AB - Autoimmune diseases, including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary antiphospholipid syndrome (APS), systemic sclerosis and systemic vasculitis, affect a large number of people in whom one of the leading causes of morbidity and mortality is cardiovascular disease. Cardiovascular disease is associated with the development of accelerated atherosclerosis. It seems to occur at a younger age than in the general population, is often asymptomatic and, in addition to traditional risk factors, also involves specific risk factors as chronic inflammation, the duration and activity of the autoimmune disease, and immunosuppressive therapy. The early phases of cardiovascular involvement in patients with autoimmune diseases may be clinically silent, with only a microcirculation disorder present. There are various means of detecting morphological cardiac damage: coronary angiography remains the gold standard for diagnosing coronary stenosis, but new, non invasive and more reliable methods have been introduced into clinical practice in order to detect subclinical microcirculation abnormalities.

KW - Coronary angiography

KW - Microcirculation abnormalities

KW - Non-invasive diagnostic tools

KW - Systemic autoimmune diseases

UR - http://www.scopus.com/inward/record.url?scp=61349135624&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61349135624&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2008.08.004

DO - 10.1016/j.autrev.2008.08.004

M3 - Article

C2 - 18817899

AN - SCOPUS:61349135624

VL - 8

SP - 281

EP - 286

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 4

ER -