Cardiovascular phenotype of young adults and angiotensinogen alleles

Riccardo Sarzani, Paolo Dessì-Fulgheri, Domenico Mazzara, Roberto Catalini, Giovanna Cola, Giovanni Bersigotti, Nicoletta Siragusa, Fabio Salvi, Pietro Ercolani, Diego Spagnolo, Oriana Zingaretti, Massimiliano Serenelli, Mauro Pupita, Caterina M. Magni, Laura Giantomassi, Roberta Pasquini, Rosaria Gesuita, Flavia Carle, Alessandro Rappelli

Research output: Contribution to journalArticle

Abstract

Objectives and Design: Angiotensinogen (AGT) gene variants influence angiotensinogen plasma levels in children and young adults. The angiotensinogen promoter (-6)A variant facilitates gene transcription in human tissues and it has been associated with high blood pressure in older adults. A young adult population can be used as a model to study genotype/phenotype associations between AGT (-6) variants and cardiovascular variables. Methods and Results: Anthropometric measurements, blood pressure and heart rate were taken in 422 white Caucasian students (mean age 23.5 years, SD 2.5 years). Family history for hypertension, physical activity and smoking history were evaluated. Left ventricular variables were measured by echocardiography. Carotid artery wall intimal-media thickness (IMT) was measured by high resolution sonography and digitalized morphometry. The AGT G(-6)A alleles were evaluated by mutagenically separated polymerase chain reaction controlled by direct sequencing. No significant associations were found between angiotensinogen genotype and blood pressure, cardiac variables [except for deceleration time in females which increased with the number of (-6)A alleles] and IMT. Allele frequencies were similar between the first and third tertile of blood pressure and left ventricular mass, and were also similar between negative or positive family history for hypertension (the last group having significantly higher systolic blood pressure in males, P=0.04 and diastolic blood pressure in females, P

Original languageEnglish
Pages (from-to)2171-2178
Number of pages8
JournalJournal of Hypertension
Volume19
Issue number12
DOIs
Publication statusPublished - 2001

Keywords

  • Angiotensinogen
  • Blood pressure
  • Cardiac hypertrophy
  • Carotid arteries
  • Genetics

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

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    Sarzani, R., Dessì-Fulgheri, P., Mazzara, D., Catalini, R., Cola, G., Bersigotti, G., Siragusa, N., Salvi, F., Ercolani, P., Spagnolo, D., Zingaretti, O., Serenelli, M., Pupita, M., Magni, C. M., Giantomassi, L., Pasquini, R., Gesuita, R., Carle, F., & Rappelli, A. (2001). Cardiovascular phenotype of young adults and angiotensinogen alleles. Journal of Hypertension, 19(12), 2171-2178. https://doi.org/10.1097/00004872-200112000-00009