Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners

Andrew D’Silva, Anish N. Bhuva, Jet van Zalen, Rachel Bastiaenen, Amna Abdel-Gadir, Siana Jones, Niromila Nadarajan, Katia D. Menacho Medina, Yang Ye, Joao Augusto, Thomas A. Treibel, Stefania Rosmini, Manish Ramlall, Paul R. Scully, Camilla Torlasco, James Willis, Gherardo Finocchiaro, Efstathios Papatheodorou, Harshil Dhutia, Della ColeIrina Chis Ster, Alun D. Hughes, Rajan Sharma, Charlotte Manisty, Guy Lloyd, James C. Moon, Sanjay Sharma

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Marathon running is a popular ambition in modern societies inclusive of non-athletes. Previous studies have highlighted concerning transient myocardial dysfunction and biomarker release immediately after the race. Whether this method of increasing physical activity is beneficial or harmful remains a matter of debate. We examine in detail the real-world cardiovascular remodeling response following competition in a first marathon. Methods: Sixty-eight novice marathon runners (36 men and 32 women) aged 30 ± 3 years were investigated 6 months before and 2 weeks after the 2016 London Marathon race in a prospective observational study. Evaluation included electrocardiography, cardiopulmonary exercise testing, echocardiography, and cardiovascular magnetic resonance imaging. Results: After 17 weeks unsupervised marathon training, runners revealed a symmetrical, eccentric remodeling response with 3–5% increases in left and right ventricular cavity sizes, respectively. Blood pressure (BP) fell by 4/2 mmHg (P < 0.01) with reduction in arterial stiffness, despite only 11% demonstrating a clinically meaningful improvement in peak oxygen consumption with an overall non-significant 0.4 ml/min/kg increase in peak oxygen consumption (P = 0.14). Conclusion: In the absence of supervised training, exercise-induced cardiovascular remodeling in real-world novice marathon runners is more modest than previously described and occurs even without improvement in cardiorespiratory fitness. The responses are similar in men and women, who experience a beneficial BP reduction and no evidence of myocardial fibrosis or persistent edema, when achieving average finishing times.

Original languageEnglish
Article number232
JournalFrontiers in Physiology
Volume11
DOIs
Publication statusPublished - Mar 18 2020

Keywords

  • athlete’s heart
  • cardiorespiratory fitness
  • cardiovascular remodeling
  • endurance exercise
  • marathon
  • sports cardiology

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners'. Together they form a unique fingerprint.

Cite this