TY - JOUR
T1 - Cardiovascular risk factors and immunosuppressive regimen after liver transplantation
AU - Rossetto, A.
AU - Bitetto, D.
AU - Bresadola, V.
AU - Lorenzin, D.
AU - Baccarani, U.
AU - De Anna, D.
AU - Bresadola, F.
AU - Adani, G. L.
PY - 2010/9
Y1 - 2010/9
N2 - Cardiovascular and metabolic diseases represent important long-term complications after liver transplantation (LT), impairing long-term and disease-free survivals. A few mechanisms underlie the development of those complications, but the role of immunosuppressive drugs is major. Although several patients develop temporary metabolic diseases, which normalize after a short postoperative period and do not need long-term drug therapy, the incidences of de novo long-lasting arterial hypertension, hyperlipidemia, and diabetes mellitus are high during the first year after LT. The aim of this retrospective study was to evaluate new-onset arterial hypertension, hyperlipidemia, or diabetes among 100 LT patients at a single institution. We used chi-square statistical analysis to compare incidences during tacrolimus versus cyclosporine therapy. Hypertension did not seem to be more strongly related to tacrolimus than to cyclosporine, nor did diabetes, whereas there was a difference for the development of hyperlipidemia.
AB - Cardiovascular and metabolic diseases represent important long-term complications after liver transplantation (LT), impairing long-term and disease-free survivals. A few mechanisms underlie the development of those complications, but the role of immunosuppressive drugs is major. Although several patients develop temporary metabolic diseases, which normalize after a short postoperative period and do not need long-term drug therapy, the incidences of de novo long-lasting arterial hypertension, hyperlipidemia, and diabetes mellitus are high during the first year after LT. The aim of this retrospective study was to evaluate new-onset arterial hypertension, hyperlipidemia, or diabetes among 100 LT patients at a single institution. We used chi-square statistical analysis to compare incidences during tacrolimus versus cyclosporine therapy. Hypertension did not seem to be more strongly related to tacrolimus than to cyclosporine, nor did diabetes, whereas there was a difference for the development of hyperlipidemia.
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U2 - 10.1016/j.transproceed.2010.05.160
DO - 10.1016/j.transproceed.2010.05.160
M3 - Article
C2 - 20832547
AN - SCOPUS:77956494196
VL - 42
SP - 2576
EP - 2578
JO - Transplantation Proceedings
JF - Transplantation Proceedings
SN - 0041-1345
IS - 7
ER -