Cardiovascular risk factors and outcome in patients with retinal vein occlusion

Mirko Di Capua, Antonio Coppola, Rosina Albisinni, Antonella Tufano, Anna Guida, Matteo Nicola Dario Di Minno, Ferdinando Cirillo, Marcello Loffredo, Anna Maria Cerbone

Research output: Contribution to journalArticlepeer-review


The pathogenesis and treatment of retinal vein occlusions (RVO) are largely unclear. Prevalence of cardiovascular risk factors and of thrombophilic abnormalities was evaluated in 117 patients (61 M, 56 F; mean age 51 ± 13 years) with a history of RVO (62 central, CRVO; 48 branch, BRVO; 7 both) and in 202 age-and sex-matched control subjects. Cardiovascular outcome after a mean 8.2 year follow-up was recorded for 90 patients. Arterial hypertension was significantly more frequent in patients than in controls (64.9 vs. 28.2%; adjusted OR 4.5 95% CI 2.4-7.9; P <0.0001), as well diabetes mellitus (17.9 vs. 7.9%; P <0.05). Antithrombin, Protein C, Protein S and homocysteine levels, lupus anticoagulant, anticardiolipin antibodies, FV G1691A and prothrombin G20210A polymorphisms were comparable in the two groups, nor were different according to RVO localization or to the age at event. BRVO patients were significantly older (55 ± 9 vs. 47 ± 15 years; P = 0.002) and had higher prevalence of diabetes, overweight and hypertension (29.2 vs. 8.1%; 83.3 vs. 58.1%, 79.2 vs. 56.5%; P always

Original languageEnglish
Pages (from-to)16-22
Number of pages7
JournalJournal of Thrombosis and Thrombolysis
Issue number1
Publication statusPublished - Jul 2010


  • Cardiovascular recurrence
  • Retinal vein occlusion
  • Risk factors
  • Thrombophilia

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine
  • Medicine(all)


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