Cardiovascular Risk Factors Associated With the Metabolically Healthy Obese (MHO) Phenotype Compared to the Metabolically Unhealthy Obese (MUO) Phenotype in Children: Frontiers in Endocrinology

S. Genovesi, L. Antolini, A. Orlando, L. Gilardini, S. Bertoli, M. Giussani, C. Invitti, E. Nava, M.G. Battaglino, A. Leone, M.G. Valsecchi, G. Parati

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In pediatric age the prevalence of obesity is high. Obese children who do not have other risk factors than excess weight have been defined as “metabolically healthy obese” (MHO). Aim: The aim of this study is to evaluate, in a population of obese children, the prevalence of the MHO and “metabolically unhealthy obese” (MUO) phenotype. Furthermore, we evaluated the distribution of Uric Acid, HOMA index and Waist-Height ratio (W-Hr) in the MHO and MUO sub-groups and the impact of these non-traditional risk factors on the probability to be MUO. Methods: In 1201 obese children and adolescents [54% males, age (±SD) 11.9 (±3.0) years] weight, height, waist circumference, systolic (SBP) and diastolic (DBP) blood pressure, pubertal status, glucose, insulin, HDL cholesterol, triglycerides and Uric Acid serum values were assessed. MUO phenotype was defined as the presence of at least one of the following risk factors: SBP or DBP ≥ 90th percentile, glycaemia ≥ 100 mg/dl, HDL cholesterol
Original languageEnglish
JournalFront. Endocrinol.
Volume11
DOIs
Publication statusPublished - 2020

Keywords

  • children
  • HOMA index
  • metabolically healthy obesity
  • Uric Acid
  • waist-height ratio
  • glucose
  • high density lipoprotein cholesterol
  • insulin
  • triacylglycerol
  • uric acid
  • adolescent
  • adolescent obesity
  • adult
  • age
  • Article
  • blood biochemistry
  • body height
  • body weight
  • cardiovascular risk
  • child
  • childhood obesity
  • cohort analysis
  • diastolic blood pressure
  • female
  • glucose blood level
  • high density lipoprotein cholesterol level
  • homeostasis model assessment
  • human
  • hypertriglyceridemia
  • insulin blood level
  • Italy
  • major clinical study
  • male
  • metabolically healthy obese
  • metabolically unhealthy obese
  • prevalence
  • puberty
  • receiver operating characteristic
  • school child
  • sensitivity and specificity
  • sex difference
  • systolic blood pressure
  • triacylglycerol blood level
  • uric acid blood level
  • waist circumference
  • waist to height ratio

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