Abstract
The objective of this study was to determine, in an adolescent population, the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of NAFLD and cardiovascular risk factors with carotid artery intima-media thickness (IMT), a marker of subclinical atherosclerosis. The authors conducted a population-based study among 642 randomly selected adolescents aged 11-13 years in Reggio Calabria, southern Italy, between November 2007 and October 2008. Prevalences of overweight and obesity were 30.5% and 13.5%, respectively. The overall prevalence of NAFLD was 12.5%, increasing to 23.0% in overweight/obese adolescents. In univariate analysis, increased IMT was positively associated with the presence of NAFLD, body mass index (BMI), waist circumference, systolic blood pressure (all P's <0.001), diastolic blood pressure (P = 0.006), γ-glutamyl transpeptidase (P = 0.006), alanine aminotransferase (P = 0.007), and C-reactive protein (P = 0.008) and was inversely associated with high density lipoprotein cholesterol (P <0.001). In multivariate analysis, NAFLD (P = 0.002), BMI (P = 0.004), waist circumference (P = 0.003), and systolic blood pressure (P = 0.005) retained significant associations. The authors conclude that NAFLD, BMI, waist circumference, and systolic blood pressure are independent markers of increased IMT in a random sample of adolescents.
| Original language | English |
|---|---|
| Pages (from-to) | 1195-1202 |
| Number of pages | 8 |
| Journal | American Journal of Epidemiology |
| Volume | 171 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2010 |
Fingerprint
Keywords
- Adolescent
- Atherosclerosis
- Blood pressure
- Body mass index
- Fatty liver
- Liver diseases
- Obesity
- Sex
ASJC Scopus subject areas
- Epidemiology
Cite this
Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy. / Caserta, Carmelo Antonio; Pendino, Gaspare Maria; Amante, Angela; Vacalebre, Carmelo; Fiorillo, Maria Teresa; Surace, Pasquale; Messineo, Arianna; Surace, Monica; Alicante, Saverio; Cotichini, Rodolfo; Zuin, Massimo; Rosmini, Francesco; Mele, Alfonso; Marcucci, Fabrizio.
In: American Journal of Epidemiology, Vol. 171, No. 11, 2010, p. 1195-1202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy
AU - Caserta, Carmelo Antonio
AU - Pendino, Gaspare Maria
AU - Amante, Angela
AU - Vacalebre, Carmelo
AU - Fiorillo, Maria Teresa
AU - Surace, Pasquale
AU - Messineo, Arianna
AU - Surace, Monica
AU - Alicante, Saverio
AU - Cotichini, Rodolfo
AU - Zuin, Massimo
AU - Rosmini, Francesco
AU - Mele, Alfonso
AU - Marcucci, Fabrizio
PY - 2010
Y1 - 2010
N2 - The objective of this study was to determine, in an adolescent population, the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of NAFLD and cardiovascular risk factors with carotid artery intima-media thickness (IMT), a marker of subclinical atherosclerosis. The authors conducted a population-based study among 642 randomly selected adolescents aged 11-13 years in Reggio Calabria, southern Italy, between November 2007 and October 2008. Prevalences of overweight and obesity were 30.5% and 13.5%, respectively. The overall prevalence of NAFLD was 12.5%, increasing to 23.0% in overweight/obese adolescents. In univariate analysis, increased IMT was positively associated with the presence of NAFLD, body mass index (BMI), waist circumference, systolic blood pressure (all P's <0.001), diastolic blood pressure (P = 0.006), γ-glutamyl transpeptidase (P = 0.006), alanine aminotransferase (P = 0.007), and C-reactive protein (P = 0.008) and was inversely associated with high density lipoprotein cholesterol (P <0.001). In multivariate analysis, NAFLD (P = 0.002), BMI (P = 0.004), waist circumference (P = 0.003), and systolic blood pressure (P = 0.005) retained significant associations. The authors conclude that NAFLD, BMI, waist circumference, and systolic blood pressure are independent markers of increased IMT in a random sample of adolescents.
AB - The objective of this study was to determine, in an adolescent population, the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of NAFLD and cardiovascular risk factors with carotid artery intima-media thickness (IMT), a marker of subclinical atherosclerosis. The authors conducted a population-based study among 642 randomly selected adolescents aged 11-13 years in Reggio Calabria, southern Italy, between November 2007 and October 2008. Prevalences of overweight and obesity were 30.5% and 13.5%, respectively. The overall prevalence of NAFLD was 12.5%, increasing to 23.0% in overweight/obese adolescents. In univariate analysis, increased IMT was positively associated with the presence of NAFLD, body mass index (BMI), waist circumference, systolic blood pressure (all P's <0.001), diastolic blood pressure (P = 0.006), γ-glutamyl transpeptidase (P = 0.006), alanine aminotransferase (P = 0.007), and C-reactive protein (P = 0.008) and was inversely associated with high density lipoprotein cholesterol (P <0.001). In multivariate analysis, NAFLD (P = 0.002), BMI (P = 0.004), waist circumference (P = 0.003), and systolic blood pressure (P = 0.005) retained significant associations. The authors conclude that NAFLD, BMI, waist circumference, and systolic blood pressure are independent markers of increased IMT in a random sample of adolescents.
KW - Adolescent
KW - Atherosclerosis
KW - Blood pressure
KW - Body mass index
KW - Fatty liver
KW - Liver diseases
KW - Obesity
KW - Sex
UR - http://www.scopus.com/inward/record.url?scp=77952921855&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952921855&partnerID=8YFLogxK
U2 - 10.1093/aje/kwq073
DO - 10.1093/aje/kwq073
M3 - Article
VL - 171
SP - 1195
EP - 1202
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 11
ER -