Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy

Carmelo Antonio Caserta, Gaspare Maria Pendino, Angela Amante, Carmelo Vacalebre, Maria Teresa Fiorillo, Pasquale Surace, Arianna Messineo, Monica Surace, Saverio Alicante, Rodolfo Cotichini, Massimo Zuin, Francesco Rosmini, Alfonso Mele, Fabrizio Marcucci

Research output: Contribution to journalArticle

Abstract

The objective of this study was to determine, in an adolescent population, the prevalence of nonalcoholic fatty liver disease (NAFLD) and the association of NAFLD and cardiovascular risk factors with carotid artery intima-media thickness (IMT), a marker of subclinical atherosclerosis. The authors conducted a population-based study among 642 randomly selected adolescents aged 11-13 years in Reggio Calabria, southern Italy, between November 2007 and October 2008. Prevalences of overweight and obesity were 30.5% and 13.5%, respectively. The overall prevalence of NAFLD was 12.5%, increasing to 23.0% in overweight/obese adolescents. In univariate analysis, increased IMT was positively associated with the presence of NAFLD, body mass index (BMI), waist circumference, systolic blood pressure (all P's <0.001), diastolic blood pressure (P = 0.006), γ-glutamyl transpeptidase (P = 0.006), alanine aminotransferase (P = 0.007), and C-reactive protein (P = 0.008) and was inversely associated with high density lipoprotein cholesterol (P <0.001). In multivariate analysis, NAFLD (P = 0.002), BMI (P = 0.004), waist circumference (P = 0.003), and systolic blood pressure (P = 0.005) retained significant associations. The authors conclude that NAFLD, BMI, waist circumference, and systolic blood pressure are independent markers of increased IMT in a random sample of adolescents.

Original languageEnglish
Pages (from-to)1195-1202
Number of pages8
JournalAmerican Journal of Epidemiology
Volume171
Issue number11
DOIs
Publication statusPublished - 2010

Keywords

  • Adolescent
  • Atherosclerosis
  • Blood pressure
  • Body mass index
  • Fatty liver
  • Liver diseases
  • Obesity
  • Sex

ASJC Scopus subject areas

  • Epidemiology

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  • Cite this

    Caserta, C. A., Pendino, G. M., Amante, A., Vacalebre, C., Fiorillo, M. T., Surace, P., Messineo, A., Surace, M., Alicante, S., Cotichini, R., Zuin, M., Rosmini, F., Mele, A., & Marcucci, F. (2010). Cardiovascular risk factors, nonalcoholic fatty liver disease, and carotid artery intima-media thickness in an adolescent population in southern Italy. American Journal of Epidemiology, 171(11), 1195-1202. https://doi.org/10.1093/aje/kwq073