Cardiovascular risk in normal weight, eumenorrheic, nonhirsute daughters of patients with polycystic ovary syndrome: a pilot study

Cesare Battaglia, Fulvia Mancini, Arianna Cianciosi, Paolo Busacchi, Nicola Persico, Roberto Paradisi, Fabio Facchinetti, Domenico de Aloysio

Research output: Contribution to journalArticle


Objective: To verify whether healthy daughters with polycystic ovaries (PCO) of patients with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease in comparison with healthy controls. Design: Prospective observational study. Setting: University hospital. Patient(s): Seventeen eumenorrheic daughters with PCO of patients with PCOS (group 1) and 20 healthy volunteers (group 2) with regular ovulatory cycles. Intervention(s): Fasting blood sampling, ultrasonographic and Doppler analyses, 24-hour ambulatory blood pressure monitoring. Main Outcome Measure(s): Medical examination; blood measurement of nitrites and nitrates, biochemical and hormonal parameters; utero-ovarian ultrasonographic analysis and color Doppler evaluation of uterine and stromal ovarian arteries; brachial artery flow-mediated vasodilatation; 24-hour ambulatory blood pressure monitoring. An oral glucose tolerance test was performed to analyze glucose, insulin, and C-peptide levels. Result(s): At Doppler analysis a significantly higher uterine and a lower ovarian artery pulsatility index was found in group 1 compared with group 2. The brachial artery diameter, after the reactive hyperemia, showed a greater vasodilatation in controls in comparison with women with PCO. The 24-hour blood pressure monitoring demonstrated that patients with PCO have significant higher 24-hour, daytime, and nighttime diastolic and mean arterial pressure values than controls. The nitrites and nitrates plasma levels were lower in group 1 compared with group 2. The glucose and insulin plasma values were higher in patients with PCO than in controls. Conclusion(s): Eumenorrheic nonhirsute daughters of patients with PCOS who have PCO appearance on ultrasound have an increased cardiovascular risk.

Original languageEnglish
Pages (from-to)240-249
Number of pages10
JournalFertility and Sterility
Issue number1
Publication statusPublished - Jul 2009



  • androgens
  • brachial artery
  • Doppler
  • insulin
  • PCO
  • PCOS
  • ultrasonography

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

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