Cardiovascular risk in patients with subclinical hypothyroidism

Leonidas H. Duntas, Luca Chiovato

Research output: Contribution to journalArticlepeer-review


Subclinical hypothyroidism (SCH) has been associated with increased cardiovascular mortality due to adverse effects mainly on lipids and blood pressure (BP). There is evidence that SCH, especially in patients with thyroid-stimulating hormone (TSH) >10mU/l, may increase cardiovascular risk. Some uncertainty exists regarding the association of SCH with BP; however, that the coexistence of SCH with BP and hypercholesterolaemia has a negative cardiovascular impact is beyond doubt. Insulin resistance, by modulating various risk factors including coagulation, may potentially increase cardiovascular risk. Periodic health examinations including screening has been advised in patients >35 years of age, while treatment with thyroxine should be tailored to each patient.

Original languageEnglish
Pages (from-to)157-160
Number of pages4
JournalEuropean Endocrinology
Issue number2
Publication statusPublished - 2014


  • Blood pressure
  • Cardiovascular risk
  • Lipids
  • Subclinical hypothyroidism
  • The metabolic syndrome
  • Thyroid-stimulating hormone

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Endocrine and Autonomic Systems


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