Cardiovascular risk in women with polycystic ovary syndrome

Francesco Giallauria, Francesco Orio, Stefano Palomba, Gaetano Lombardi, Annamaria Colao, Carlo Vigorito

Research output: Contribution to journalArticlepeer-review

Abstract

Polycystic ovary syndrome (PCOS) is a heterogeneous disease affecting about 5-10% of reproductive-age female population, which is predominantly characterized by chronic anovulation, hyperandrogenism and insulin resistance. PCOS women represent an intriguing biological model illustrating the relationship between hormonal pattern and cardiovascular risk profile, presenting a cluster of cardiovascular features, such as obesity, insulin resistance, hypertension, impaired cardiopulmonary functional capacity, autonomic dysfunction and low-grade chronic inflammation. Metabolic syndrome should be also considered in the clinical evaluation and management of PCOS. The treatment of PCOS and its complications should not be based solely on pharmacological therapies trying to improve hyperandrogenism, hyperinsulinemia and insulin resistance. Although mounting evidence recognizes the beneficial effects of lifestyle modifications, the clinical management of PCOS is not sufficiently focused on long-term maintenance of both exercise and dietary interventions and on further aspects of this syndrome (i.e. psychological status). Taking into consideration the patients' young age and the devastating effects of PCOS on hormonal and metabolic pattern, this complex and multifaceted disease requires a comprehensive approach in order to achieve concrete beneficial effects for PCOS patients. Multidisciplinary programs, including dietary and educational counseling, exercise training, stress management and psychosocial support, might represent the gold standard for adequate reduction of cardiovascular risk in young women with PCOS.

Original languageEnglish
Pages (from-to)987-992
Number of pages6
JournalJournal of Cardiovascular Medicine
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Cardiovascular risk factors
  • Diet
  • Exercise training
  • Hyperandrogenemia
  • Hyperinsulinemia
  • Insulin resistance
  • Obesity
  • Polycystic ovary syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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