Cardiovascular risk markers in patients with psoriatic arthritis: A meta-analysis of literature studies

Matteo Nicola Dario Di Minno, Pasquale Ambrosino, Roberta Lupoli, Alessandro Di Minno, Marco Tasso, Rosario Peluso, Elena Tremoli

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Several studies reported an increased cardiovascular (CV) morbidity and mortality in patients with psoriatic arthritis (PsA). We performed a meta-analysis on the impact of PsA on major markers of CV risk. Methods. Studies on the relationship between PsA and common carotid artery intima-media thickness (CCA-IMT), prevalence of carotid plaques, flow-mediated dilation (FMD), nitrate-mediated dilation (NMD), pulse wave velocity (PWV), augmentation index (AIx), and ankle-brachial index (ABI) were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases. Results. Sixteen case-control studies (898 cases, 1,140 controls) were included. Compared to controls, PsA patients showed a higher CCA-IMT (MD 0.07 mm; 95% CI 0.04, 0.11; P <0.0001), and a higher frequency of carotid plaques (OR 3.12; 95% CI 1.03, 9.39; P = 0.04). Moreover, a lower FMD was found in PsA subjects than in controls (MD-2.56%; 95% CI-4.17,-0.94; P = 0.002), with no differences in NMD (MD-0.40%; 95% CI-1.19, 0.39; P = 0.32). Because of the low number of studies, no meta-analytical evaluation was performed for PWV, AIx, and ABI. Despite heterogeneity among studies, PsA appears significantly associated with markers of subclinical atherosclerosis and CV risk. Discussion. These findings could help to establish more specific CV prevention strategies in this clinical setting.

Original languageEnglish
Pages (from-to)346-353
Number of pages8
JournalAnnals of Medicine
Volume47
Issue number4
DOIs
Publication statusPublished - Jun 1 2015

Keywords

  • Carotid plaques
  • Flow-mediated dilation
  • Intima-media thickness
  • Psoriatic arthritis
  • Subclinical atherosclerosis

ASJC Scopus subject areas

  • Medicine(all)

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