TY - JOUR
T1 - Cardiovascular risk markers in patients with psoriatic arthritis
T2 - A meta-analysis of literature studies
AU - Di Minno, Matteo Nicola Dario
AU - Ambrosino, Pasquale
AU - Lupoli, Roberta
AU - Di Minno, Alessandro
AU - Tasso, Marco
AU - Peluso, Rosario
AU - Tremoli, Elena
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Introduction. Several studies reported an increased cardiovascular (CV) morbidity and mortality in patients with psoriatic arthritis (PsA). We performed a meta-analysis on the impact of PsA on major markers of CV risk. Methods. Studies on the relationship between PsA and common carotid artery intima-media thickness (CCA-IMT), prevalence of carotid plaques, flow-mediated dilation (FMD), nitrate-mediated dilation (NMD), pulse wave velocity (PWV), augmentation index (AIx), and ankle-brachial index (ABI) were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases. Results. Sixteen case-control studies (898 cases, 1,140 controls) were included. Compared to controls, PsA patients showed a higher CCA-IMT (MD 0.07 mm; 95% CI 0.04, 0.11; P <0.0001), and a higher frequency of carotid plaques (OR 3.12; 95% CI 1.03, 9.39; P = 0.04). Moreover, a lower FMD was found in PsA subjects than in controls (MD-2.56%; 95% CI-4.17,-0.94; P = 0.002), with no differences in NMD (MD-0.40%; 95% CI-1.19, 0.39; P = 0.32). Because of the low number of studies, no meta-analytical evaluation was performed for PWV, AIx, and ABI. Despite heterogeneity among studies, PsA appears significantly associated with markers of subclinical atherosclerosis and CV risk. Discussion. These findings could help to establish more specific CV prevention strategies in this clinical setting.
AB - Introduction. Several studies reported an increased cardiovascular (CV) morbidity and mortality in patients with psoriatic arthritis (PsA). We performed a meta-analysis on the impact of PsA on major markers of CV risk. Methods. Studies on the relationship between PsA and common carotid artery intima-media thickness (CCA-IMT), prevalence of carotid plaques, flow-mediated dilation (FMD), nitrate-mediated dilation (NMD), pulse wave velocity (PWV), augmentation index (AIx), and ankle-brachial index (ABI) were systematically searched in the PubMed, Web of Science, Scopus, and EMBASE databases. Results. Sixteen case-control studies (898 cases, 1,140 controls) were included. Compared to controls, PsA patients showed a higher CCA-IMT (MD 0.07 mm; 95% CI 0.04, 0.11; P <0.0001), and a higher frequency of carotid plaques (OR 3.12; 95% CI 1.03, 9.39; P = 0.04). Moreover, a lower FMD was found in PsA subjects than in controls (MD-2.56%; 95% CI-4.17,-0.94; P = 0.002), with no differences in NMD (MD-0.40%; 95% CI-1.19, 0.39; P = 0.32). Because of the low number of studies, no meta-analytical evaluation was performed for PWV, AIx, and ABI. Despite heterogeneity among studies, PsA appears significantly associated with markers of subclinical atherosclerosis and CV risk. Discussion. These findings could help to establish more specific CV prevention strategies in this clinical setting.
KW - Carotid plaques
KW - Flow-mediated dilation
KW - Intima-media thickness
KW - Psoriatic arthritis
KW - Subclinical atherosclerosis
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U2 - 10.3109/07853890.2015.1031822
DO - 10.3109/07853890.2015.1031822
M3 - Article
C2 - 25953378
AN - SCOPUS:84930509080
VL - 47
SP - 346
EP - 353
JO - Annales medicinae experimentalis et biologiae Fenniae
JF - Annales medicinae experimentalis et biologiae Fenniae
SN - 0785-3890
IS - 4
ER -