Cardiovascular safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients: A prospective evaluation

Veronica Prati; Fiorella Ruatta; Caterina Aversa; Angela Gernone; Danilo Galizia; Alessandro Bonzano; Sofia Torino; Imperia Nuzzolese; Laura Marandino; Massimo Aglietta; Cinzia Ortega

doi:10.2217/fon-2017-0385

Cardiovascular safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients: A prospective evaluation

Veronica Prati, Fiorella Ruatta, Caterina Aversa, Angela Gernone, Danilo Galizia, Alessandro Bonzano, Sofia Torino, Imperia Nuzzolese, Laura Marandino, Massimo Aglietta, Cinzia Ortega

Istituto Oncologico Candiolo

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: The aim of this study is to evaluate cardiotoxicity of abiraterone acetate (AA) in metastatic castration-resistant prostate cancer patients (pts) with cardiovascular comorbidities or coronary artery disease (CAD) risk factors. Patients & methods: We prospectively analyzed pts receiving AA in order to evaluate correlations between cardiotoxicity onset and CAD risk factors or cardiovascular comorbidities. Results: Eighty-seven pts were enrolled, with median treatment duration of 9 months (1-44). At baseline, 84 pts (96%) had CAD risk factors. During treatment four pts (4; 6%) developed hypertension and 26 pts (30%) worsened the preexisting hypertension. Median left ventricular ejection fraction were 64 and 63% at baseline and after treatment, respectively. Conclusion: AA appears to be safe in pts with cardiovascular comorbidities or CAD risk factors.

Original language	English
Pages (from-to)	443-448
Number of pages	6
Journal	Future Oncology
Volume	14
Issue number	5
DOIs	https://doi.org/10.2217/fon-2017-0385
Publication status	Published - Feb 1 2018

Keywords

abiraterone acetate
cardiovascular risk factors
frail patients
metastatic castration-resistant prostate cancer
multidisciplinary management
prospective study
safety

ASJC Scopus subject areas

Oncology
Cancer Research

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Cardiovascular safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients : A prospective evaluation. / Prati, Veronica; Ruatta, Fiorella; Aversa, Caterina; Gernone, Angela; Galizia, Danilo ; Bonzano, Alessandro; Torino, Sofia; Nuzzolese, Imperia; Marandino, Laura; Aglietta, Massimo; Ortega, Cinzia.

In: Future Oncology, Vol. 14, No. 5, 01.02.2018, p. 443-448.

Research output: Contribution to journal › Article › peer-review

Prati, Veronica ; Ruatta, Fiorella ; Aversa, Caterina ; Gernone, Angela ; Galizia, Danilo ; Bonzano, Alessandro ; Torino, Sofia ; Nuzzolese, Imperia ; Marandino, Laura ; Aglietta, Massimo ; Ortega, Cinzia. / Cardiovascular safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients : A prospective evaluation. In: Future Oncology. 2018 ; Vol. 14, No. 5. pp. 443-448.

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abstract = "Aim: The aim of this study is to evaluate cardiotoxicity of abiraterone acetate (AA) in metastatic castration-resistant prostate cancer patients (pts) with cardiovascular comorbidities or coronary artery disease (CAD) risk factors. Patients & methods: We prospectively analyzed pts receiving AA in order to evaluate correlations between cardiotoxicity onset and CAD risk factors or cardiovascular comorbidities. Results: Eighty-seven pts were enrolled, with median treatment duration of 9 months (1-44). At baseline, 84 pts (96%) had CAD risk factors. During treatment four pts (4; 6%) developed hypertension and 26 pts (30%) worsened the preexisting hypertension. Median left ventricular ejection fraction were 64 and 63% at baseline and after treatment, respectively. Conclusion: AA appears to be safe in pts with cardiovascular comorbidities or CAD risk factors.",

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AU - Gernone, Angela

AU - Galizia, Danilo

AU - Bonzano, Alessandro

AU - Torino, Sofia

AU - Nuzzolese, Imperia

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AU - Aglietta, Massimo

AU - Ortega, Cinzia

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Cardiovascular safety of abiraterone acetate in metastatic castration-resistant prostate cancer patients: A prospective evaluation

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Keywords

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