Cardiovascular side-effects of common antibiotics

Francesco Amati, Marta Di Pasquale, Marcos I. Restrepo, Judith Marin-Corral, Stefano Aliberti, Francesco Blasi

Research output: Contribution to journalArticle

Abstract

Two of the most prescribed classes of antibiotic in respiratory medicine, macrolides and fluoroquinolones, are associated with cardiovascular side-effects. The antibiotic-related cardiovascular morbidity and mortality are linked to arrhythmia, ischaemic events, and aortic dissection or bleeding. However, the cardiovascular risk of antibiotics is higher in the subgroup of patients with risk factors for arrhythmia, ischaemic CVEs and aortic dissection. Therefore, identifying this subgroup of patients at high risk is of paramount importance. The aim of this chapter is to review antibiotic-induced adverse CVEs, particularly in high-risk patients. The mechanisms inducing these events and the gaps in real-life data are also explored. Finally, we propose an algorithm to identify patients at risk for CVEs and to monitor those undergoing macrolide and fluoroquinolone treatment.

Original languageEnglish
Pages (from-to)264-278
Number of pages15
JournalERS Monograph
Volume2020
Issue number9781849841191
DOIs
Publication statusPublished - 2020

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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