Cardioverter-defibrillator implantation in myeloma-associated cardiac amyloidosis

Alfonso Campanile, Fabiola B. Sozzi, Ciro Canetta, Gian Battista Danzi

Research output: Contribution to journalArticle


A 62-year-old woman with multiple myeloma and light-chain amyloidosis with significant heart involvement developed an in-hospital cardiac arrest. After cardiopulmonary resuscitation, a stable sinus rhythm without any cerebral damage was restored, and the patient was admitted to the coronary care unit. A cardioverter-defibrillator was implanted, and it successfully intervened in two sustained ventricular tachycardia episodes and one ventricular fibrillation episode, which were recorded during hospitalization. After achieving discrete cardiac compensation, the patient was transferred to the emergency medicine department where she underwent chemotherapy for multiple myeloma. The patient died 40 days after admission from refractory heart failure. In the literature, there are studies that describe the use of cardioverter-defibrillator implantation in cardiac amyloidosis; however, at present, there is no evidence of a beneficial effect on survival with the use of this intervention. A high index of suspicion for amyloid heart disease and early diagnosis are critical to improving outcomes.

Original languageEnglish
Pages (from-to)31-34
Number of pages4
JournalExperimental and Clinical Cardiology
Issue number1
Publication statusPublished - Mar 2013


  • Amyloid heart disease
  • Cardioverter-defibrillator
  • Restrictive cardiomyopathy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)
  • Physiology

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