Carditis, intestinal metaplasia and adenocarcinoma of oesophagogastric junction

M. Conio, R. Filiberti, S. Blanchi, A. Giacosa

Research output: Contribution to journalArticle

Abstract

Barrett's oesophagus is a precancerous condition in which the normal squamous epithelium is replaced by intestinal metaplasia (IM). IM can then progress through increasingly severe dysplasia to oesophageal adenocarcinoma (EAC). In the gastric cardia the normal gastric mucosa, when inflamed (carditis), can be replaced by IM and can then progress to gastric adenocarcinoma (GAC). The same histopathological sequence can take place on either side of the oesophagogastric junction. Since the location of that junction can be uncertain this can result in confused diagnosis between EAC and GAC. In this review, the diagnostic criteria, incidence and risk factors for Barrett's oesophagus and carditis are discussed, together with the factors determining the risk of progression to adenocarcinoma of the oesophagus or cardia. The risk factors include familial/genetic, environmental and dietary characteristics. Finally, these risk factors are discussed within the context of cancer prevention.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalEuropean Journal of Cancer Prevention
Volume10
Issue number6
DOIs
Publication statusPublished - 2001

Keywords

  • Barrett's oesophagus
  • Cancer of the cardia
  • Cancer prevention
  • Carditis
  • Intestinal metaplasia
  • Oesophageal adenocarcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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