Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: A 1-year follow-up prospective study

Alessandro Clemenzi, Rita Formisano, Maria Matteis, Luciano Gallinacci, Giulio Cochi, Paola Savina, Paola Cicinelli

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate the efficacy and the safety of repeated botulinum toxin type A (BT-A) injections in patients with severe acquired brain injury (ABI) and to gain a better knowledge of possible clinical or demographic characteristics associated with a better rehabilitation outcome. Design: Prospective study with a 1-year follow-up period. Subjects: Twenty-one patients with spasticity due to severe ABI and no further improving with rehabilitation treatment and oral anti-spastic drugs. Intervention: Repeated BT-A injections associated to a rehabilitation programme. Main measures: Barthel Index (BI), Modified Ashworth Score (MAS) and VAS score for pain subjective perception were recorded. Results: At the end of the follow-up study, MAS, BI and VAS significantly improved. Despite the number of BT-A injections, a shorter interval between severe ABI onset and first BT-A treatment correlated to a better BI improvement. None of the patients experienced adverse events attributable to BT-A. Conclusion: BT-A was effective and safe in the treatment of spasticity in severe ABI patients, with a better functional outcome in those subjects treated earlier after spasticity onset. The lack of correlation between clinical outcome and number of injections suggests, in addition to a direct inhibition at the neuromuscular junction, a more distant BT-A long-term effect.

Original languageEnglish
Pages (from-to)979-983
Number of pages5
JournalBrain Injury
Volume26
Issue number7-8
DOIs
Publication statusPublished - Jul 2012

Keywords

  • Botulinum toxin type A
  • Severe acquired brain injury
  • Spasticity

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Fingerprint

Dive into the research topics of 'Care management of spasticity with botulinum toxin-A in patients with severe acquired brain injury: A 1-year follow-up prospective study'. Together they form a unique fingerprint.

Cite this